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thrC threonine synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945198, updated on 4-Feb-2026
Official Symbol
thrC
Official Full Name
threonine synthase
Primary source
ECOCYC:EG11000
Locus tag
b0004
See related
ASAP:ABE-0000012
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0004
Summary
Threonine synthase (ThrC) carries out the second step in the biosynthesis of threonine from homoserine, and the final step in overall threonine biosynthesis. [More information is available at EcoCyc: EG11000].
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Sequence:
NC_000913.3 (3734..5020)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene fused aspartate kinase/homoserine dehydrogenase 1 Neighboring gene homoserine kinase Neighboring gene DUF2502 domain-containing protein YaaX Neighboring gene DNA binding and peroxide stress response protein YaaA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Threonine synthase of Escherichia coli: inhibition by classical and slow-binding analogues of homoserine phosphate. Farrington GK, et al. Arch Biochem Biophys, 1993 Nov 15. PMID 7902068
  2. Mechanisms of interaction of Escherichia coli threonine synthase with substrates and inhibitors. Laber B, et al. Biochemistry, 1994 Mar 22. PMID 7907888
  3. Construction and expression of a hybrid plasmid containing the Escherichia coli thrA and thrB genes. Cossart P, et al. Mol Gen Genet, 1979 Aug. PMID 390305
  4. Interaction of aspartate and aspartate-derived antimetabolites with the enzymes of the threonine biosynthetic pathway of Escherichia coli. Shames SL, et al. J Biol Chem, 1984 Dec 25. PMID 6150934
  5. PROSITE: a dictionary of sites and patterns in proteins. Bairoch A. Nucleic Acids Res, 1992 May 11. PMID 1598232, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: '98 Escherichia coli SWISS-2DPAGE database update.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables threonine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables threonine synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-threonine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-threonine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
threonine synthase
NP_414545.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3734..5020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414545.1 threonine synthase

    See identical proteins and their annotated locations for NP_414545.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S7EFT0
    Conserved Domains (1) summary
    PRK09225
    Location:1 → 428
    PRK09225; threonine synthase; Validated
Nucleotide Protein
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