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mhpA 3-(3-hydroxyphenyl)propanoate hydroxylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945197, updated on 30-Jul-2025
Official Symbol
mhpA
Official Full Name
3-(3-hydroxyphenyl)propanoate hydroxylase
Primary source
ECOCYC:M010
Locus tag
b0347
See related
ASAP:ABE-0001196
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0344
Summary
visC, ubiH, ubiF and mhpA are paralogs. [More information is available at EcoGene: EG20273].
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Try the new Transcripts and proteins table
Sequence:
NC_000913.3 (368611..370275)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor LacI Neighboring gene DNA-binding transcriptional activator MhpR Neighboring gene 3-carboxyethylcatechol 2,3-dioxygenase Neighboring gene 2-hydroxy-6-ketonona-2,4-dienedioate hydrolase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Regulation of the mhp cluster responsible for 3-(3-hydroxyphenyl)propionic acid degradation in Escherichia coli. Torres B, et al. J Biol Chem, 2003 Jul 25. PMID 12748194
  2. Overproduction, purification and properties of 2,3-dihydroxyphenylpropionate 1,2-dioxygenase from Escherichia coli. Bugg TD. Biochim Biophys Acta, 1993 Oct 6. PMID 8399388
  3. Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli. Burlingame R, et al. J Bacteriol, 1983 Jul. PMID 6345502, Free PMC Article
  4. Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation. Burlingame RP, et al. J Bacteriol, 1986 Oct. PMID 3531186, Free PMC Article
  5. The SWISS-PROT protein sequence data bank, recent developments. Bairoch A, et al. Nucleic Acids Res, 1993 Jul 1. PMID 8332529, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-(3-hydroxyphenyl)propionate hydroxylase activity EXP
Inferred from Experiment
more info
 PubMed 
enables 3-(3-hydroxyphenyl)propionate hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-(3-hydroxyphenyl)propionate hydroxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-(3-hydroxyphenyl)propionate hydroxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables FAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 3-(3-hydroxy)phenylpropionate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 3-(3-hydroxy)phenylpropionate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within 3-(3-hydroxy)phenylpropionate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in 3-phenylpropionate catabolic process IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
3-(3-hydroxyphenyl)propanoate hydroxylase
NP_414881.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    368611..370275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414881.1 3-(3-hydroxyphenyl)propanoate hydroxylase

    See identical proteins and their annotated locations for NP_414881.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376MRW1
    Conserved Domains (1) summary
    PRK06183
    Location:1 → 544
    mhpA; bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase
Nucleotide Protein
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