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iscX accessory iron-sulfur cluster assembly protein IscX [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945196, updated on 3-Dec-2024

Summary

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Official Symbol
iscX
Official Full Name
accessory iron-sulfur cluster assembly protein IscX
Primary source
ECOCYC:EG12311
Locus tag
b2524
See related
ASAP:ABE-0008309
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2521; yfhJ
Summary
IscX physically interacts with IscS . [More information is available at EcoCyc: EG12311].
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Genomic context

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Sequence:
NC_000913.3 (2656536..2656736, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein SseB Neighboring gene aminopeptidase B Neighboring gene reduced ferredoxin Neighboring gene iron-sulfur cluster biosynthesis chaperone HscA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of IscX in iron-sulfur cluster biogenesis in Escherichia coli. Kim JH, et al. J Am Chem Soc, 2014 Jun 4. PMID 24810328, Free PMC Article
  2. The iron-binding CyaY and IscX proteins assist the ISC-catalyzed Fe-S biogenesis in Escherichia coli. Roche B, et al. Mol Microbiol, 2015 Feb. PMID 25430730
  3. Hsc66, an Hsp70 homolog in Escherichia coli, is induced by cold shock but not by heat shock. Lelivelt MJ, et al. J Bacteriol, 1995 Sep. PMID 7665466, Free PMC Article
  4. A gene encoding a DnaK/hsp70 homolog in Escherichia coli. Seaton BL, et al. Proc Natl Acad Sci U S A, 1994 Mar 15. PMID 8134349, Free PMC Article
  5. Cloning, sequencing, and overexpression of a [2Fe-2S] ferredoxin gene from Escherichia coli. Ta DT, et al. J Biol Chem, 1992 Jun 5. PMID 1317854

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a genetic interaction was discovered between cyaY and iscX; validates IscX as a new bona fide Fe-S cluster biogenesis factor
    Title: The iron-binding CyaY and IscX proteins assist the ISC-catalyzed Fe-S biogenesis in Escherichia coli.
  2. Crystal structure of Escherichia coli YfhJ protein
    Title: Crystal structure of Escherichia coli YfhJ protein, a member of the ISC machinery involved in assembly of iron-sulfur clusters.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrous iron binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within iron-sulfur cluster assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
accessory iron-sulfur cluster assembly protein IscX

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2656536..2656736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417019.1 accessory iron-sulfur cluster assembly protein IscX [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417019.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376VE87
    Conserved Domains (1) summary
    PRK10721
    Location:1 → 66
    PRK10721; hypothetical protein; Provisional
Nucleotide Protein
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