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cusB copper/silver export system membrane fusion protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945189, updated on 23-Nov-2023

Summary

Gene symbol
cusB
Gene description
copper/silver export system membrane fusion protein
Primary source
ASAP:ABE-0001969
Locus tag
b0574
See related
ECOCYC:G6322
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0566; ylcD
Summary
cusB is in the cusCFBA Cu/Ag efflux operon regulated by Cu and Ag. [More information is available at EcoGene: EG14235]. CusB is a membrane fusion protein involved in the detoxification of copper and silver ions in Escherichia coli as part of the CusCFBA copper/silver efflux system. [More information is available at EcoCyc: G6322].
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Genomic context

Sequence:
NC_000913.3 (597479..598702)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene copper/silver export system outer membrane channel Neighboring gene copper/silver export system periplasmic binding protein Neighboring gene copper/silver export system RND permease Neighboring gene phenylalanine:H(+) symporter PheP

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables copper ion transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transition metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transition metal ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within copper ion export IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in copper ion export NAS
Non-traceable Author Statement
more info
PubMed 
involved_in copper ion transmembrane transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in copper ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within detoxification of copper ion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within detoxification of copper ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular copper ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intracellular copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within plasma membrane copper ion transport IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to copper ion IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to copper ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to silver ion IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to silver ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
involved_in response to toxic substance NAS
Non-traceable Author Statement
more info
PubMed 
involved_in silver ion transmembrane transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cell envelope IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
copper/silver export system membrane fusion protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    597479..598702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415106.1 copper/silver export system membrane fusion protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415106.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EK49
    Conserved Domains (1) summary
    PRK09783
    Location:1407
    PRK09783; copper/silver efflux system membrane fusion protein CusB; Provisional