napD NapA signal peptide-binding chaperone NapD [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Gene symbol: napD
Gene description: NapA signal peptide-binding chaperone NapD
Primary source: ASAP:ABE-0007291
Locus tag: b2207
See related: ECOCYC:EG12143
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK2199; yojF
Summary: Nap has a strong anti-transport actvity in vitro, but is essential for NapA activity and transport in vivo. [More information is available at EcoGene: EG12143]. NapD is a dedicated chaperone for NapA, the molybdoprotein subunit of the periplasmic nitrate reductase. [More information is available at EcoCyc: EG12143].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The NapA signal peptide adopts an alpha-helical conformation upon binding NapD.
Title: Overlapping transport and chaperone-binding functions within a bacterial twin-arginine signal peptide.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signal sequence binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables signal sequence binding	IEA Inferred from Electronic Annotation more info
enables signal sequence binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of protein transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within negative regulation of protein transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain