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ompT omptin family outer membrane protease OmpT [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945185, updated on 26-Mar-2025

Summary

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Official Symbol
ompT
Official Full Name
omptin family outer membrane protease OmpT
Primary source
ECOCYC:EG10673
Locus tag
b0565
See related
ASAP:ABE-0001931
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0557
Summary
Mg(2+) stimulon-PhoPQ regulon, EvgAS-PhoPQ cascade enhanced-expression subset. [More information is available at EcoGene: EG10673]. OmpT is an outer membrane protease with specificity for paired basic residues ; detailed studies on substrate specificity have been performed . [More information is available at EcoCyc: EG10673].
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Genomic context

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Sequence:
NC_000913.3 (584680..585633, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein TfaX Neighboring gene DNA-binding transcriptional activator AppY Neighboring gene DNA-binding transcriptional activator EnvY Neighboring gene putative exopolysaccharide secretion system auxiliary component

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vitro folding, purification and characterization of Escherichia coli outer membrane protease ompT. Kramer RA, et al. Eur J Biochem, 2000 Feb. PMID 10651827
  2. OmpT: molecular dynamics simulations of an outer membrane enzyme. Baaden M, et al. Biophys J, 2004 Nov. PMID 15315948, Free PMC Article
  3. Investigation into the interaction of the bacterial protease OmpT with outer membrane lipids and biological activity of OmpT:lipopolysaccharide complexes. Brandenburg K, et al. Eur Biophys J, 2005 Feb. PMID 15241571
  4. Utilization of Escherichia coli outer-membrane endoprotease OmpT variants as processing enzymes for production of peptides from designer fusion proteins. Okuno K, et al. Appl Environ Microbiol, 2004 Jan. PMID 14711628, Free PMC Article
  5. Distribution and genetic association of putative uropathogenic virulence factors iroN, iha, kpsMT, ompT and usp in Escherichia coli isolated from urinary tract infections in Japan. Kanamaru S, et al. J Urol, 2003 Dec. PMID 14634457

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that OmpT plays a multifaceted role in pathogenesis of urinary tract infection, including increased bacterial adhesiveness/invasiveness, formation of intracellular bacterial communities and upregulated proinflammatory cytokines.
    Title: Role of uropathogenic Escherichia coli outer membrane protein T in pathogenesis of urinary tract infection.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
omptin family outer membrane protease OmpT
NP_415097.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    584680..585633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415097.1 omptin family outer membrane protease OmpT [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415097.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376DE95, G9FSR4
    Conserved Domains (1) summary
    PRK10993
    Location:1 → 317
    PRK10993; omptin family outer membrane protease
Nucleotide Protein
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