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rfbA glucose-1-phosphate thymidylyltransferase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945154, updated on 30-Jul-2025
Official Symbol
rfbA
Official Full Name
glucose-1-phosphate thymidylyltransferase 1
Primary source
ECOCYC:EG11978
Locus tag
b2039
See related
ASAP:ABE-0006762
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2033; rmlA; som
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Try the new Transcripts and proteins table
Sequence:
NC_000913.3 (2110138..2111019, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative O-antigen polymerase Neighboring gene UDP-galactopyranose mutase Neighboring gene polyisoprenol-linked O16-antigen repeat unit flippase Neighboring gene dTDP-4-dehydrorhamnose 3,5-epimerase Neighboring gene dTDP-4-dehydrorhamnose reductase Neighboring gene dTDP-glucose 4,6-dehydratase 1 Neighboring gene UTP:glucose-1-phosphate uridylyltransferase, low activity

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. [RmlA gene deletion affects biofilm formation by avian pathogenic Escherichia coli]. Han Y, et al. Wei Sheng Wu Xue Bao, 2013 Oct 4. PMID 24409761
  2. Kinetic and crystallographic analyses support a sequential-ordered bi bi catalytic mechanism for Escherichia coli glucose-1-phosphate thymidylyltransferase. Zuccotti S, et al. J Mol Biol, 2001 Nov 2. PMID 11697907
  3. Era and RbfA have overlapping function in ribosome biogenesis in Escherichia coli. Inoue K, et al. J Mol Microbiol Biotechnol, 2006. PMID 16825789
  4. Molecular typing of Escherichia coli strains isolated from food in Casablanca (Morocco). Badri S, et al. Cell Mol Biol (Noisy-le-grand), 2009 Jun 15. PMID 19656466
  5. Function of the rfb gene cluster and the rfe gene in the synthesis of O antigen by Shigella dysenteriae 1. Klena JD, et al. Mol Microbiol, 1993 Jul. PMID 7692219

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The rmlA deletion mutant did not affect the growth and motility but enhanced the biofilm formation.
    Title: [RmlA gene deletion affects biofilm formation by avian pathogenic Escherichia coli].
  2. Results showed a reproducible and clear cut classification with molecular polymorphism of rfb gene cluster and flagella gene fliC.
    Title: Molecular typing of Escherichia coli strains isolated from food in Casablanca (Morocco).
  3. Era and RbfA have an overlapping function that is essential for ribosome biogenesis.
    Title: Era and RbfA have overlapping function in ribosome biogenesis in Escherichia coli.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glucose-1-phosphate thymidylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose-1-phosphate thymidylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucose-1-phosphate thymidylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in O antigen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dTDP-rhamnose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in polysaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
glucose-1-phosphate thymidylyltransferase 1
NP_416543.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2110138..2111019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416543.1 glucose-1-phosphate thymidylyltransferase 1

    See identical proteins and their annotated locations for NP_416543.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5C9AK78
    Conserved Domains (1) summary
    TIGR01207
    Location:5 → 290
    rmlA; glucose-1-phosphate thymidylyltransferase, short form
Nucleotide Protein
Heading Accession and Version

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