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acrA multidrug efflux pump membrane fusion lipoprotein AcrA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945112, updated on 26-Mar-2022

Summary

Gene symbol
acrA
Gene description
multidrug efflux pump membrane fusion lipoprotein AcrA
Primary source
ASAP:ABE-0001603
Locus tag
b0463
See related
ECOCYC:EG11703
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0457; lir; Mb; mbl; mtcA; nbsA; sipB
Summary
acrA was first identified as an acridine sensitive mutation. acrA is a mutational suppressor of topA deletion inviability in low osmolarity medium. [More information is available at EcoGene: EG11703]. AcrA is the periplasmic lipoprotein component of the AcrAB-TolC multidrug efflux pump in Escherichia coli and can function in chimeric constructions with three other RND-family pumps, AcrD, AcrF and YhiV. [More information is available at EcoCyc: EG11703].
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Genomic context

Sequence:
NC_000913.3 (484426..485619, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene Hha toxicity modulator TomB Neighboring gene multidrug efflux pump RND permease AcrB Neighboring gene DNA-binding transcriptional repressor AcrR Neighboring gene potassium dependent, small conductance mechanosensitive channel

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables alkane transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables bile acid transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of efflux pump complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in intrinsic component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
multidrug efflux pump membrane fusion lipoprotein AcrA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    484426..485619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414996.1 multidrug efflux pump membrane fusion lipoprotein AcrA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414996.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0AE06
    Conserved Domains (1) summary
    PRK15030
    Location:1397
    PRK15030; multidrug efflux RND transporter periplasmic adaptor subunit AcrA