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acrB multidrug efflux pump RND permease AcrB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945108, updated on 26-Nov-2024

Summary

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Official Symbol
acrB
Official Full Name
multidrug efflux pump RND permease AcrB
Primary source
ECOCYC:EG11704
Locus tag
b0462
See related
ASAP:ABE-0001601
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
acrE; ECK0456
Summary
acrB is an acrF paralog. [More information is available at EcoGene: EG11704]. AcrB is an RND-type inner-membrane associate proton-substrate antiporter. [More information is available at EcoCyc: EG11704].
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Genomic context

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Sequence:
NC_000913.3 (481254..484403, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene hemolysin expression-modulating protein Hha Neighboring gene Hha toxicity modulator TomB Neighboring gene multidrug efflux pump membrane fusion lipoprotein AcrA Neighboring gene DNA-binding transcriptional repressor AcrR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crucial role of Asp408 in the proton translocation pathway of multidrug transporter AcrB: evidence from site-directed mutagenesis and carbodiimide labeling. Seeger MA, et al. Biochemistry, 2009 Jun 30. PMID 19425588
  2. 3D structure of AcrB: the archetypal multidrug efflux transporter of Escherichia coli likely captures substrates from periplasm. Elkins CA, et al. Drug Resist Updat, 2003 Feb. PMID 12654283
  3. Switch-loop flexibility affects transport of large drugs by the promiscuous AcrB multidrug efflux transporter. Cha HJ, et al. Antimicrob Agents Chemother, 2014 Aug. PMID 24914123, Free PMC Article
  4. Unfolding study of a trimeric membrane protein AcrB. Ye C, et al. Protein Sci, 2014 Jul. PMID 24715637, Free PMC Article
  5. Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Yu EW, et al. Science, 2003 May 9. PMID 12738864

See all (156) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proximal Binding Pocket Arg717 Substitutions in Escherichia coli AcrB Cause Clinically Relevant Divergencies in Resistance Profiles.
    Title: Proximal Binding Pocket Arg717 Substitutions in Escherichia coli AcrB Cause Clinically Relevant Divergencies in Resistance Profiles.
  2. In situ structure of the AcrAB-TolC efflux pump at subnanometer resolution.
    Title: In situ structure of the AcrAB-TolC efflux pump at subnanometer resolution.
  3. Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps.
    Title: Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps.
  4. Metabolomics Reveal Potential Natural Substrates of AcrB in Escherichia coli and Salmonella enterica Serovar Typhimurium.
    Title: Metabolomics Reveal Potential Natural Substrates of AcrB in Escherichia coli and Salmonella enterica Serovar Typhimurium.
  5. Allosteric drug transport mechanism of multidrug transporter AcrB.
    Title: Allosteric drug transport mechanism of multidrug transporter AcrB.
  6. Studying dynamics without explicit dynamics: A structure-based study of the export mechanism by AcrB.
    Title: Studying dynamics without explicit dynamics: A structure-based study of the export mechanism by AcrB.
  7. Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment.
    Title: Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment.
  8. Substrate-dependent transport mechanism in AcrB of multidrug resistant bacteria.
    Title: Substrate-dependent transport mechanism in AcrB of multidrug resistant bacteria.
  9. Discovery of multidrug efflux pump inhibitors with a novel chemical scaffold.
    Title: Discovery of multidrug efflux pump inhibitors with a novel chemical scaffold.
  10. Cryo-EM analysis of a membrane protein embedded in the liposome.
    Title: Cryo-EM analysis of a membrane protein embedded in the liposome.
Submit: New GeneRIF Correction See all GeneRIFs (66)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables alkane transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables bile acid transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables efflux transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables enterobactin transmembrane transporter activity EXP
Inferred from Experiment
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables xenobiotic transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables xenobiotic transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in alkane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in bile acid and bile salt transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in enterobactin transport EXP
Inferred from Experiment
more info
 PubMed 
involved_in fatty acid transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to antibiotic IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to toxic substance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to xenobiotic stimulus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of efflux pump complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of efflux pump complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in periplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
multidrug efflux pump RND permease AcrB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    481254..484403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414995.1 multidrug efflux pump RND permease AcrB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414995.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A895P5Q3
    Conserved Domains (1) summary
    PRK15127
    Location:1 → 1049
    PRK15127; multidrug efflux RND transporter permease subunit AcrB
Nucleotide Protein
Heading Accession and Version

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