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ftsK cell division DNA translocase FtsK [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945102, updated on 4-Feb-2026
Official Symbol
ftsK
Official Full Name
cell division DNA translocase FtsK
Primary source
ECOCYC:G6464
Locus tag
b0890
See related
ASAP:ABE-0003027
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
dinH; ECK0881
Summary
FtsK is required for resolution of chromosome dimers at dif by XerCD. [More information is available at EcoGene: EG13226]. FtsK is an essential cell division protein which colocalizes with FtsZ to the septal ring structure; localization is dependent on FtsZ, FtsA and ZipA, but not FtsI and FtsQ . [More information is available at EcoCyc: G6464].
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Sequence:
NC_000913.3 (933224..937213)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene thioredoxin reductase Neighboring gene DNA-binding transcriptional dual regulator Lrp Neighboring gene outer membrane lipoprotein carrier protein Neighboring gene replication-associated recombination protein A

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Study of polymorphic variable-number of tandem repeats loci in the ECOR collection and in a set of pathogenic Escherichia coli and Shigella isolates for use in a genotyping assay. Lindstedt BA, et al. J Microbiol Methods, 2007 Apr. PMID 17291612
  2. Sequence-directed DNA translocation by purified FtsK. Pease PJ, et al. Science, 2005 Jan 28. PMID 15681387
  3. FtsK: Maxwell's Demon? Donachie WD. Mol Cell, 2002 Feb. PMID 11864592
  4. Analysis of DNA supercoil induction by FtsK indicates translocation without groove-tracking. Saleh OA, et al. Nat Struct Mol Biol, 2005 May. PMID 15821742
  5. Delayed activation of Xer recombination at dif by FtsK during septum assembly in Escherichia coli. Kennedy SP, et al. Mol Microbiol, 2008 May. PMID 18363794

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein interaction of FtsK with FTsA is essential to cell division.
    Title: FtsA G50E mutant suppresses the essential requirement for FtsK during bacterial cell division in Escherichia coli.
  2. Deletion of rlpA from an FtsK temperature-sensitive E. coli strain partially restored cell growth and largely suppressed cellular filamentation compared to the wild-type strain. This suggests that interaction with RlpA may be critical in suppressing septation until proper assembly of the divisome.
    Title: Outer membrane lipoprotein RlpA is a novel periplasmic interaction partner of the cell division protein FtsK in Escherichia coli.
  3. FtsKgamma interacts with the C-terminal domain of XerD, above a cleft where XerC is thought to bind. We present a model for activation of recombination based on structural data.
    Title: Activation of Xer-recombination at dif: structural basis of the FtsKγ-XerD interaction.
  4. We found that whatever the growth conditions, sister copies of the V. cholerae chr1 dif region remain together at mid-cell until the onset of constriction, which permits their processing by FtsK and the activation of dif-recombination.
    Title: Fast growth conditions uncouple the final stages of chromosome segregation and cell division in Escherichia coli.
  5. FtsK translocase has a role in assembly, translocation, and activation of XerCD-dif recombination
    Title: Assembly, translocation, and activation of XerCD-dif recombination by FtsK translocase analyzed in real-time by FRET and two-color tethered fluorophore motion.
  6. An average of 7 FtsK hexamers per cell are present at midcell, with the N-terminal domain being able to hexamerize independently of the translocase.
    Title: The N-terminal membrane-spanning domain of the Escherichia coli DNA translocase FtsK hexamerizes at midcell.
  7. Kinetic analyses showed that the presence of the FtsK gamma domain increases the rate of XerCD-dif synapse assembly and increases its stability.
    Title: TPM analyses reveal that FtsK contributes both to the assembly and the activation of the XerCD-dif recombination synapse.
  8. Data indicate that the arrival of the FtsK translocase at an initial synaptic complex, forming a transient activated complex in which XerD exchanged a pair of strands to form an Holliday junctions (HJ) intermediate for catalysis by XerC.
    Title: Conformational transitions during FtsK translocase activation of individual XerCD-dif recombination complexes.
  9. FtsK segregates the terminus region of sister chromosomes whether they are monomeric or dimeric and does so in an accurate and ordered manner.
    Title: FtsK actively segregates sister chromosomes in Escherichia coli.
  10. Multiple regions in FtsK protein are required for in cell division.
    Title: Multiple regions along the Escherichia coli FtsK protein are implicated in cell division.
Submit: New GeneRIF Correction See all GeneRIFs (30)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA translocase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA translocase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA helicase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in FtsZ-dependent cytokinesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in FtsZ-dependent cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cellular response to antibiotic IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to antibiotic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chromosome segregation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in division septum assembly NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within septum digestion after cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell division site NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane EXP
Inferred from Experiment
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
cell division DNA translocase FtsK

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    933224..937213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415410.1 cell division DNA translocase FtsK

    See identical proteins and their annotated locations for NP_415410.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A377DUH0
    Conserved Domains (1) summary
    PRK10263
    Location:1 → 1329
    PRK10263; DNA translocase FtsK; Provisional
Nucleotide Protein
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