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dps DNA protection during starvation protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945101, updated on 25-Jun-2025
Official Symbol
dps
Official Full Name
DNA protection during starvation protein
Primary source
ECOCYC:EG11415
Locus tag
b0812
See related
ASAP:ABE-0002776
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0801; pexB; vtm
Summary
dps is required for growth below 8C, which is enabled by transgenic Oleispira antarctica Cpn10/60. [More information is available at EcoGene: EG11415]. Dps is a highly abundant protein in stationary-phase Escherichia coli and is required for the normal starvation response and long-term stationary phase viability . [More information is available at EcoCyc: EG11415].
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Sequence:
NC_000913.3 (848408..848911, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-glutamine ABC transporter ATP binding subunit Neighboring gene L-glutamine ABC transporter membrane subunit Neighboring gene L-glutamine ABC transporter periplasmic binding protein Neighboring gene L-threonine/L-homoserine exporter Neighboring gene protein YliM

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Analysis of protein synthesis rates after initiation of chromosome replication in Escherichia coli. Bechtloff D, et al. J Bacteriol, 1999 Oct. PMID 10515917, Free PMC Article
  2. Acid stress damage of DNA is prevented by Dps binding in Escherichia coli O157:H7. Jeong KC, et al. BMC Microbiol, 2008 Oct 15. PMID 18922164, Free PMC Article
  3. DNA condensation and self-aggregation of Escherichia coli Dps are coupled phenomena related to the properties of the N-terminus. Ceci P, et al. Nucleic Acids Res, 2004. PMID 15534364, Free PMC Article
  4. Dps protects cells against multiple stresses during stationary phase. Nair S, et al. J Bacteriol, 2004 Jul. PMID 15205421, Free PMC Article
  5. Fundamental structural units of the Escherichia coli nucleoid revealed by atomic force microscopy. Kim J, et al. Nucleic Acids Res, 2004. PMID 15060178, Free PMC Article

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bridging DNA contacts allow Dps from E. coli to condense DNA.
    Title: Bridging DNA contacts allow Dps from E. coli to condense DNA.
  2. Multi-crystal data collection using synchrotron radiation as exemplified with low-symmetry crystals of Dps.
    Title: Multi-crystal data collection using synchrotron radiation as exemplified with low-symmetry crystals of Dps.
  3. Structural Rearrangement of Dps-DNA Complex Caused by Divalent Mg and Fe Cations.
    Title: Structural Rearrangement of Dps-DNA Complex Caused by Divalent Mg and Fe Cations.
  4. Spatial organization of Dps and DNA-Dps complexes.
    Title: Spatial organization of Dps and DNA-Dps complexes.
  5. A double-alanine mutant of E. coli Dps protein is unable to assemble into a cage due to disruption of key protein-protein interactions. Randomization of residues surrounding the double mutation afforded a repacked interface and proteins with recovered cage formation.
    Title: A Structure-Based Assembly Screen of Protein Cage Libraries in Living Cells: Experimentally Repacking a Protein-Protein Interface To Recover Cage Formation in an Assembly-Frustrated Mutant.
  6. three new candidates of E. coli nucleoid, namely DNA-binding protein from starved cells (Dps), host factor for phage Qbeta (Hfq) and suppressor of td(-) phenotype A (StpA)
    Title: Growth phase dependent changes in the structure and protein composition of nucleoid in Escherichia coli.
  7. Oxidative stress response proteins such as AhpF, Dps, and Fur, all of which belong to the oxyR regulon, were upregulated in Escherichia coli isolates from mice fed the lactose-rich diet.
    Title: Impact of nutritional factors on the proteome of intestinal Escherichia coli: induction of OxyR-dependent proteins AhpF and Dps by a lactose-rich diet.
  8. study investigated the role key protein-protein interactions play in the assembly and stability of the DPS mini-ferritin
    Title: Rational disruption of the oligomerization of the mini-ferritin E. coli DPS through protein-protein interface mutation.
  9. Unexpectedly, the authors found that dps expression is directly repressed by Mn(2+)-MntR.
    Title: The Escherichia coli K-12 MntR miniregulon includes dps, which encodes the major stationary-phase DNA-binding protein.
  10. In contrast, cells lacking Dps exhibited increased cellular copper concentrations compared to their wild-type parent.
    Title: The Dps protein of Escherichia coli is involved in copper homeostasis.
Submit: New GeneRIF Correction See all GeneRIFs (15)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferric iron binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated DNA replication initiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of DnaA-Dps complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DnaA-Dps complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane HDA PubMed 
Preferred Names
DNA protection during starvation protein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    848408..848911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415333.1 DNA protection during starvation protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415333.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376MU58
    Conserved Domains (1) summary
    PRK09448
    Location:7 → 167
    PRK09448; DNA starvation/stationary phase protection protein Dps; Provisional
Nucleotide Protein
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