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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_016424.1 RefSeqGene
- Range
-
5113..75836
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_1024
mRNA and Protein(s)
-
NM_001313915.2 → NP_001300844.1 eukaryotic translation initiation factor 2-alpha kinase 3 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an alternate 5' exon, uses an alternate 5' terminal exon, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
- Source sequence(s)
-
AC062029, AC104134, CB162654, CR749382
- UniProtKB/TrEMBL
- A0A804HIT4, B3KY45, Q68DI6
- Related
- ENSP00000507214.1, ENST00000682892.1
- Conserved Domains (3) summary
-
- cd09768
Location:1 → 269
- Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
- cd14048
Location:722 → 924
- STKc_EIF2AK3_PERK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase
- cl21453
Location:436 → 512
- PKc_like; Protein Kinases, catalytic domain
-
NM_004836.7 → NP_004827.4 eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor
See identical proteins and their annotated locations for NP_004827.4
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
- Source sequence(s)
-
AC062029, AC104134, AK128659, CB162654
- Consensus CDS
-
CCDS33241.1
- UniProtKB/Swiss-Prot
- A0AVH1, A0AVH2, B2RCU9, O95846, Q53QY0, Q53SB1, Q9NZJ5
- UniProtKB/TrEMBL
- B3KY45, Q68DI6
- Related
- ENSP00000307235.3, ENST00000303236.9
- Conserved Domains (3) summary
-
- cd09768
Location:104 → 420
- Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
- cd14048
Location:873 → 1075
- STKc_EIF2AK3_PERK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase
- cl21453
Location:587 → 663
- PKc_like; Protein Kinases, catalytic domain