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lon Lon protease [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945085, updated on 22-Jun-2021

Summary

Gene symbol
lon
Gene description
Lon protease
Primary source
ASAP:ABE-0001521
Locus tag
b0439
See related
ECOCYC:EG10542
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
capR; deg; dir; ECK0433; lopA; muc
Summary
Lon dependent lethality is due to induction of yefM-yoeb toxin/antitoxin pair. [More information is available at EcoGene: EG10542]. Lon is an ATP-dependent protease responsible for degradation of misfolded proteins as well as a number of rapidly degraded regulatory proteins. [More information is available at EcoCyc: EG10542].
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Genomic context

Sequence:
NC_000913.3 (458888..461242)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ATP-dependent Clp protease proteolytic subunit Neighboring gene ATP-dependent Clp protease ATP-binding subunit ClpX Neighboring gene DNA-binding protein HU-beta Neighboring gene periplasmic folding chaperone

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP-dependent peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type peptidase activity RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    458888..461242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414973.1 Lon protease [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414973.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0A9M0
    Conserved Domains (1) summary
    PRK10787
    Location:1784
    PRK10787; DNA-binding ATP-dependent protease La; Provisional
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