U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

nusB transcription antitermination protein NusB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945054, updated on 3-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
nusB
Official Full Name
transcription antitermination protein NusB
Primary source
ECOCYC:EG10666
Locus tag
b0416
See related
ASAP:ABE-0001447
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0410; groNB; ssaD; ssyB
Summary
Transcription antitermination protein NusB is involved in antitermination in the transcription of a number of genes. [More information is available at EcoCyc: EG10666].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (435137..435556)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene fused diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase Neighboring gene 6,7-dimethyl-8-ribityllumazine synthase Neighboring gene thiamine monophosphate kinase Neighboring gene phosphatidylglycerophosphatase A Neighboring gene 1-deoxyxylulose-5-phosphate synthase YajO

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cooperative effects of bacterial mutations affecting lambda N gene expression. I. Isolation and characterization of a nusB mutant. Friedman DI, et al. Virology, 1976 Aug. PMID 785802
  2. Involvement of the nusB gene products in transcription of Escherichia coli tryptophan operon in vitro. Kuroki K, et al. Mol Gen Genet, 1982. PMID 7045592
  3. ssaD1, a suppressor of secA51(Ts) that renders growth of Escherichia coli cold sensitive, is an early amber mutation in the transcription factor gene nusB. Rajapandi T, et al. J Bacteriol, 1994 Jul. PMID 8021230, Free PMC Article
  4. Molecular cloning and nucleotide sequencing of the nusB gene of E. coli. Ishii S, et al. Nucleic Acids Res, 1984 Jun 25. PMID 6330694, Free PMC Article
  5. Studies on the NusB protein of Escherichia coli--expression and determination of secondary-structure elements by multinuclear NMR spectroscopy. Berglechner F, et al. Eur J Biochem, 1997 Sep 1. PMID 9346286

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conservation of putative NusB/E binding sites upstream of Nus factor genes suggests that Nus factor autoregulation occurs in many bacterial species.
    Title: Identification of regulatory targets for the bacterial Nus factor complex.
  2. Authors propose that another major role for the Nus-modified transcription complex in rrn operons is as an RNA chaperone insuring co-ordination of 16S rRNA folding and RNase III processing that results in production of proper 30S ribosome subunits.
    Title: Nus transcription elongation factors and RNase III modulate small ribosome subunit biogenesis in Escherichia coli.
  3. Strains carrying either a nusA mutation or a nusB mutation have defects in transcription of 23S rRNA.
    Title: Transcriptional polarity in rRNA operons of Escherichia coli nusA and nusB mutant strains.
  4. NusB and NusE (S10) proteins binding to boxA RNA nucleates the formation of the antitermination complex involved in controlling rRNA transcription in Escherichia coli
    Title: Assembly of an RNA-protein complex. Binding of NusB and NusE (S10) proteins to boxA RNA nucleates the formation of the antitermination complex involved in controlling rRNA transcription in Escherichia coli.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription termination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription elongation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription antitermination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription antitermination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
transcription antitermination protein NusB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    435137..435556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414950.1 transcription antitermination protein NusB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414950.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377B156
    Conserved Domains (1) summary
    PRK00202
    Location:11 → 139
    nusB; transcription antitermination factor NusB
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.