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dinI DNA damage-inducible protein I [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945022, updated on 26-Mar-2025

Summary

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Official Symbol
dinI
Official Full Name
DNA damage-inducible protein I
Primary source
ECOCYC:G6558
Locus tag
b1061
See related
ASAP:ABE-0003599
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1046
Summary
DinI inhibits RecA co-protease activity of UmuD, but not LexA. [More information is available at EcoGene: EG12670]. The dinI gene was first identified as a chromosomal locus containing a high affinity operator for the LexA repressor . [More information is available at EcoCyc: G6558].
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Genomic context

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Sequence:
NC_000913.3 (1121242..1121487, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene N-methyl-L-tryptophan oxidase Neighboring gene regulator of biofilm formation Neighboring gene dihydroorotase Neighboring gene putative lipid-binding lipoprotein YceB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein mimicry of DNA and pathway regulation. Putnam CD, et al. DNA Repair (Amst), 2005 Dec 8. PMID 16226493
  2. A model for the abrogation of the SOS response by an SOS protein: a negatively charged helix in DinI mimics DNA in its interaction with RecA. Voloshin ON, et al. Genes Dev, 2001 Feb 15. PMID 11230150, Free PMC Article
  3. Two modes of binding of DinI to RecA filament provide a new insight into the regulation of SOS response by DinI protein. Galkin VE, et al. J Mol Biol, 2011 May 20. PMID 21458462, Free PMC Article
  4. DinI and RecX modulate RecA-DNA structures in Escherichia coli K-12. Renzette N, et al. Mol Microbiol, 2007 Jan. PMID 17163974
  5. The DinI protein stabilizes RecA protein filaments. Lusetti SL, et al. J Biol Chem, 2004 Jul 16. PMID 15138263

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DinI either binds to the C-terminus of a RecA protomer or DinI resides deeply in the groove of the RecA filament, with its negatively charged C-terminal helix proximal to the L2 loop of RecA.
    Title: Two modes of binding of DinI to RecA filament provide a new insight into the regulation of SOS response by DinI protein.
  2. DinI and RecX are competing modulators of RecA function
    Title: The DinI and RecX proteins are competing modulators of RecA function.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in SOS response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within SOS response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in SOS response IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA damage-inducible protein I

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1121242..1121487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415579.1 DNA damage-inducible protein I [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415579.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1X3J436, A0A1X3JIT0, A0AA36KWT0, Q1RD96
    Conserved Domains (1) summary
    PRK10597
    Location:1 → 81
    PRK10597; DNA damage-inducible protein I; Provisional
Nucleotide Protein
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