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dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945019, updated on 19-Sep-2024

Summary

Official Symbol
dxr
Official Full Name
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Primary source
ECOCYC:EG12715
Locus tag
b0173
See related
ASAP:ABE-0000592
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0172; ispC; yaeM
Summary
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr) catalyzes the first committed step in the methylerythritol phosphate pathway of isoprenoid biosynthesis. [More information is available at EcoCyc: EG12715].
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Genomic context

Sequence:
NC_000913.3 (193521..194717)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene UMP kinase Neighboring gene ribosome-recycling factor Neighboring gene ncRNA Neighboring gene ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables NADPH binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NADPH binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables manganese ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Dxr protein complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
1-deoxy-D-xylulose 5-phosphate reductoisomerase
NP_414715.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    193521..194717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414715.1 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414715.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3L5GZ07, A0A5B9AL13, A0A8S7RUP4
    Conserved Domains (1) summary
    TIGR00243
    Location:1398
    Dxr; 1-deoxy-D-xylulose 5-phosphate reductoisomerase