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pepD peptidase D [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945013, updated on 30-Jul-2025
Official Symbol
pepD
Official Full Name
peptidase D
Primary source
ECOCYC:EG10695
Locus tag
b0237
See related
ASAP:ABE-0000809
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0238; pepH
Summary
CsgD regulon, repressed. [More information is available at EcoGene: EG10695]. Peptidase D is a dipeptidase capable of breaking down a number of dipeptides with unblocked N termini, including cysteinylglycine . [More information is available at EcoCyc: EG10695].
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Sequence:
NC_000913.3 (254259..255716, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative N-acetyltransferase YafP Neighboring gene pseudo Neighboring gene pseudo Neighboring gene xanthine-guanine phsophoribosyltransferase Neighboring gene fermentation-respiration switch protein

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A dipeptidase from Escherichia coli B. Patterson EK. Methods Enzymol, 1976. PMID 13264
  2. Regulation of the biosynthesis of aminoacyl-transfer ribonucleic acid synthetases and of transfer ribonucleic acid in Escherichia coli. VI. Mutants with increased levels of glutaminyl-transfer ribonucleic acid synthetase and of glutamine transfer ribonucleic acid. Cheung A, et al. J Bacteriol, 1979 Jul. PMID 378954, Free PMC Article
  3. The promoter region of the Escherichia coli pepD gene: deletion analysis and control by phosphate concentration. Henrich B, et al. Mol Gen Genet, 1992 Mar. PMID 1313142
  4. Cloning and expression of the pepD gene of Escherichia coli. Klein J, et al. J Gen Microbiol, 1986 Aug. PMID 3540199
  5. Peptidase D gene (pepD) of Escherichia coli K-12: nucleotide sequence, transcript mapping, and comparison with other peptidase genes. Henrich B, et al. J Bacteriol, 1990 Aug. PMID 1695895, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Peptidase D of Escherichia coli K-12, a metallopeptidase of low substrate specificity.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables dipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallodipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallodipeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptide catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
peptidase D
NP_414772.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    254259..255716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414772.1 peptidase D

    See identical proteins and their annotated locations for NP_414772.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5B9AM32
    Conserved Domains (1) summary
    PRK15026
    Location:1 → 485
    PRK15026; aminoacyl-histidine dipeptidase; Provisional
Nucleotide Protein
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