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mhpE 4-hydroxy-2-oxovalerate aldolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945012, updated on 6-Jun-2024

Summary

Gene symbol
mhpE
Gene description
4-hydroxy-2-oxovalerate aldolase
Primary source
ASAP:ABE-0001209
Locus tag
b0352
See related
ECOCYC:G6205
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0349
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Genomic context

Sequence:
NC_000913.3 (373868..374881)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 2-hydroxy-6-ketonona-2,4-dienedioate hydrolase Neighboring gene 2-hydroxypentadienoate hydratase Neighboring gene acetaldehyde dehydrogenase (acetylating) MhpF Neighboring gene 3-hydroxyphenylpropionate/3-hydroxycinnamate:H(+) symporter Neighboring gene DUF2058 domain-containing protein YaiL

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2-isopropylmalate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 4-hydroxy-2-oxovalerate aldolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 4-hydroxy-2-oxovalerate aldolase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in 3-phenylpropionate catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in L-leucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in catabolic process IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
4-hydroxy-2-oxovalerate aldolase
NP_414886.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    373868..374881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414886.1 4-hydroxy-2-oxovalerate aldolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414886.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376DCC7, A0A5B9AM61
    Conserved Domains (1) summary
    PRK08195
    Location:3333
    PRK08195; 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated