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cusR DNA-binding transcriptional activator CusR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945003, updated on 30-Jul-2025
Official Symbol
cusR
Official Full Name
DNA-binding transcriptional activator CusR
Primary source
ECOCYC:G6319
Locus tag
b0571
See related
ASAP:ABE-0001948
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0563; ylcA
Summary
CusR, "Cu-sensing regulator", regulates genes related to the copper and silver efflux systems under anaerobic growth and under extreme copper stress in aerobic growth . [More information is available at EcoCyc: G6319].
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Sequence:
NC_000913.3 (594760..595443, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative exopolysaccharide secretion system auxiliary component Neighboring gene exopolysaccharide secretion system outer membrane protein NfrA Neighboring gene cyclic di-3',5'-guanylate-activated glycosyltransferase Neighboring gene sensor histidine kinase CusS Neighboring gene copper/silver export system outer membrane channel Neighboring gene copper/silver export system periplasmic binding protein

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12. Munson GP, et al. J Bacteriol, 2000 Oct. PMID 11004187, Free PMC Article
  2. Bacterial silver resistance: molecular biology and uses and misuses of silver compounds. Silver S. FEMS Microbiol Rev, 2003 Jun. PMID 12829274
  3. The product of the ybdE gene of the Escherichia coli chromosome is involved in detoxification of silver ions. Franke S, et al. Microbiology (Reading), 2001 Apr. PMID 11283292
  4. Escherichia coli mechanisms of copper homeostasis in a changing environment. Rensing C, et al. FEMS Microbiol Rev, 2003 Jun. PMID 12829268
  5. System-level mapping of Escherichia coli response regulator dimerization with FRET hybrids. Gao R, et al. Mol Microbiol, 2008 Sep. PMID 18631241, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphorelay response regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to copper ion IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
DNA-binding transcriptional activator CusR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    594760..595443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415103.1 DNA-binding transcriptional activator CusR

    See identical proteins and their annotated locations for NP_415103.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A478L557
    Conserved Domains (1) summary
    PRK09836
    Location:1 → 227
    PRK09836; DNA-binding transcriptional activator CusR; Provisional
Nucleotide Protein
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