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LY86 lymphocyte antigen 86 [ Homo sapiens (human) ]

Gene ID: 9450, updated on 1-Jun-2020

Summary

Official Symbol
LY86provided by HGNC
Official Full Name
lymphocyte antigen 86provided by HGNC
Primary source
HGNC:HGNC:16837
See related
Ensembl:ENSG00000112799 MIM:605241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MD1; MD-1; MMD-1; dJ80N2.1
Expression
Biased expression in lymph node (RPKM 17.5), spleen (RPKM 16.2) and 13 other tissues See more
Orthologs

Genomic context

See LY86 in Genome Data Viewer
Location:
6p25.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (6588639..6654982)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (6588934..6655216)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene LY86 antisense RNA 1 Neighboring gene small nuclear RNA activating complex polypeptide 5 pseudogene 1 Neighboring gene calponin 3 pseudogene 1 Neighboring gene uncharacterized LOC101928004 Neighboring gene uncharacterized LOC101928047 Neighboring gene uncharacterized LOC105374901

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
NHGRI GWA Catalog
Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lipopolysaccharide-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lymphocyte antigen 86
Names
MD-1, RP105-associated
ly-86
protein MD-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004271.4NP_004262.1  lymphocyte antigen 86 precursor

    See identical proteins and their annotated locations for NP_004262.1

    Status: VALIDATED

    Source sequence(s)
    BC038846, CD695164
    Consensus CDS
    CCDS4498.1
    UniProtKB/Swiss-Prot
    O95711
    Related
    ENSP00000230568.3, ENST00000230568.5
    Conserved Domains (1) summary
    cd00915
    Location:30159
    MD-1_MD-2; MD-1 and MD-2 are cofactors required for LPS signaling through cell surface receptors. MD-2 and its binding partner, Toll-like receptor 4 (TLR4), are essential for the innate immune responses of mammalian cells to bacterial lipopolysaccharide (LPS); MD-2 ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    6588639..6654982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011505.1XP_016866994.1  lymphocyte antigen 86 isoform X1

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