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CD33 CD33 molecule [ Homo sapiens (human) ]

Gene ID: 945, updated on 8-Jul-2018
Official Symbol
CD33provided by HGNC
Official Full Name
CD33 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1659
See related
Ensembl:ENSG00000105383 MIM:159590; Vega:OTTHUMG00000182891
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p67; SIGLEC3; SIGLEC-3
Expression
Broad expression in spleen (RPKM 7.5), bone marrow (RPKM 6.6) and 19 other tissues See more
Orthologs
See CD33 in Genome Data Viewer
Location:
19q13.41
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (51211054..51240019)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51728335..51743274)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sialic acid binding Ig like lectin 21, pseudogene Neighboring gene microRNA 8074 Neighboring gene sialic acid binding Ig like lectin 22, pseudogene Neighboring gene uncharacterized LOC107985327 Neighboring gene SIGLEC family like 1 Neighboring gene long intergenic non-protein coding RNA 1872 Neighboring gene sialic acid binding Ig like lectin 24, pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
NHGRI GWA Catalog
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.
NHGRI GWA Catalog
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates CD33 in HEK 293T cells PubMed
Vpr vpr HIV-1 Vpr downregulates CD33 expression in PBMC PubMed

Go to the HIV-1, Human Interaction Database

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ00391

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
regulation of immune response TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 
Preferred Names
myeloid cell surface antigen CD33
Names
CD33 antigen (gp67)
CD33 molecule transcript
gp67
sialic acid-binding Ig-like lectin 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082618.1NP_001076087.1  myeloid cell surface antigen CD33 isoform 2

    See identical proteins and their annotated locations for NP_001076087.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2, also known as CD33m), compared to isoform 1.
    Source sequence(s)
    AW007749, AY162464, BP303860
    Consensus CDS
    CCDS46157.1
    UniProtKB/Swiss-Prot
    P20138
    Related
    ENSP00000410126.1, OTTHUMP00000270424, ENST00000421133.6, OTTHUMT00000464200
    Conserved Domains (1) summary
    pfam00047
    Location:19100
    ig; Immunoglobulin domain
  2. NM_001177608.1NP_001171079.1  myeloid cell surface antigen CD33 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK304810, AK309558, BP295158
    Consensus CDS
    CCDS54299.1
    UniProtKB/Swiss-Prot
    P20138
    Related
    ENSP00000375673.2, OTTHUMP00000270422, ENST00000391796.7, OTTHUMT00000464198
    Conserved Domains (3) summary
    smart00410
    Location:26128
    IG_like; Immunoglobulin like
    pfam00047
    Location:146227
    ig; Immunoglobulin domain
    cl11960
    Location:23139
    Ig; Immunoglobulin domain
  3. NM_001772.3NP_001763.3  myeloid cell surface antigen CD33 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001763.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as CD33M.
    Source sequence(s)
    AW007749, BC028152, BP303860
    Consensus CDS
    CCDS33084.1
    UniProtKB/Swiss-Prot
    P20138
    UniProtKB/TrEMBL
    Q546G0
    Related
    ENSP00000262262.3, OTTHUMP00000270423, ENST00000262262.4, OTTHUMT00000464199
    Conserved Domains (3) summary
    smart00410
    Location:26128
    IG_like; Immunoglobulin like
    pfam00047
    Location:146227
    ig; Immunoglobulin domain
    cl11960
    Location:23139
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    51211054..51240019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027508.1XP_016882997.1  myeloid cell surface antigen CD33 isoform X1

    Conserved Domains (3) summary
    smart00410
    Location:80182
    IG_like; Immunoglobulin like
    pfam00047
    Location:200281
    ig; Immunoglobulin domain
    cl11960
    Location:77193
    Ig; Immunoglobulin domain
  2. XM_017027509.1XP_016882998.1  myeloid cell surface antigen CD33 isoform X2

  3. XM_017027510.1XP_016882999.1  myeloid cell surface antigen CD33 isoform X4

  4. XM_011527532.2XP_011525834.1  myeloid cell surface antigen CD33 isoform X3

    See identical proteins and their annotated locations for XP_011525834.1

    UniProtKB/Swiss-Prot
    P20138
    UniProtKB/TrEMBL
    Q546G0
    Conserved Domains (3) summary
    smart00410
    Location:26128
    IG_like; Immunoglobulin like
    pfam00047
    Location:146227
    ig; Immunoglobulin domain
    cl11960
    Location:23139
    Ig; Immunoglobulin domain
  5. XM_011527531.2XP_011525833.1  myeloid cell surface antigen CD33 isoform X1

    Conserved Domains (3) summary
    smart00410
    Location:80182
    IG_like; Immunoglobulin like
    pfam00047
    Location:200281
    ig; Immunoglobulin domain
    cl11960
    Location:77193
    Ig; Immunoglobulin domain
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