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pyrH UMP kinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944989, updated on 6-May-2021

Summary

Gene symbol
pyrH
Gene description
UMP kinase
Primary source
ASAP:ABE-0000582
Locus tag
b0171
See related
ECOCYC:EG11539
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0170; smbA; umk
Summary
Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG11539]. Expression of uridylate kinase is essential for growth of Escherichia coli . [More information is available at EcoCyc: EG11539].
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Genomic context

Sequence:
NC_000913.3 (191855..192580)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 30S ribosomal subunit protein S2 Neighboring gene protein chain elongation factor EF-Ts Neighboring gene ribosome-recycling factor Neighboring gene 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables UMP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables UMP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables UMP kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables uridylate kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    191855..192580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414713.1 UMP kinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414713.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0A7E9
    Conserved Domains (1) summary
    cd04254
    Location:10240
    AAK_UMPK-PyrH-Ec; UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and ...
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