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frmA S-(hydroxymethyl)glutathione dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944988, updated on 3-Dec-2024

Summary

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Official Symbol
frmA
Official Full Name
S-(hydroxymethyl)glutathione dehydrogenase
Primary source
ECOCYC:EG50010
Locus tag
b0356
See related
ASAP:ABE-0001221
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
adhC; ECK0353
Summary
The frmRAB operon is negatively regulated by frmR, is induced by formaldehyde, and probably degrades formaldehyde. [More information is available at EcoGene: EG50010]. Glutathione-dependent formaldehyde dehydrogenase (GS-FDH) belongs to the family of class III alcohol dehydrogenases. [More information is available at EcoCyc: EG50010].
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Genomic context

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Sequence:
NC_000913.3 (378462..379571, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2058 domain-containing protein YaiL Neighboring gene S-formylglutathione hydrolase FrmB Neighboring gene DNA-binding transcriptional repressor FrmR Neighboring gene outer membrane protein YaiO

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Thiophene-degrading Escherichia coli mutants possess sulfone oxidase activity and show altered resistance to sulfur-containing antibiotics. Juhl MJ, et al. Appl Environ Microbiol, 1990 Oct. PMID 2285321, Free PMC Article
  2. Purification, characterization, and partial sequence of the glutathione-dependent formaldehyde dehydrogenase from Escherichia coli: a class III alcohol dehydrogenase. Gutheil WG, et al. Biochemistry, 1992 Jan 21. PMID 1731906
  3. Regulatory mutations that allow the growth of Escherichia coli on butanol as carbon source. Clark DP, et al. J Mol Evol, 1987. PMID 3116274
  4. Global transcriptional effects of a suppressor tRNA and the inactivation of the regulator frmR. Herring CD, et al. J Bacteriol, 2004 Oct. PMID 15466022, Free PMC Article
  5. A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Lasserre JP, et al. Electrophoresis, 2006 Aug. PMID 16858726

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Purification, characterization, and partial sequence of the glutathione-dependent formaldehyde dehydrogenase from Escherichia coli: a class III alcohol dehydrogenase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables S-nitrosoglutathione reductase (NADH) activity IEA
Inferred from Electronic Annotation
more info
  
enables alcohol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alcohol dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in formaldehyde catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in formaldehyde catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within formaldehyde catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
S-(hydroxymethyl)glutathione dehydrogenase
NP_414890.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    378462..379571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414890.1 S-(hydroxymethyl)glutathione dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414890.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1MVC5, A0A5B9AWG4, A0A8H9SJQ1
    Conserved Domains (1) summary
    cd08300
    Location:1 → 368
    alcohol_DH_class_III; class III alcohol dehydrogenases
Nucleotide Protein
Heading Accession and Version

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