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mltA membrane-bound lytic murein transglycosylase A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944964, updated on 22-Sep-2022

Summary

Gene symbol
mltA
Gene description
membrane-bound lytic murein transglycosylase A
Primary source
ASAP:ABE-0009228
Locus tag
b2813
See related
ECOCYC:G7457
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2809; mlt; ygdM
Summary
MltA cleaves the glycosidic bonds between the N-acetylmuramic acid and N-acetylglucosamine residues in murein. [More information is available at EcoGene: EG13085]. MltA is one of six (along with MltB, MltC, MltD, EmtA, and Slt70) major lytic endotransglycosylases expressed in Escherichia coli. [More information is available at EcoCyc: G7457].
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Genomic context

Sequence:
NC_000913.3 (2946081..2947178, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cysteine sulfinate desulfinase Neighboring gene sulfur acceptor protein CsdE Neighboring gene tRNA threonylcarbamoyladenosine dehydratase Neighboring gene tRNA-Met Neighboring gene tRNA-Met

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables lytic transglycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lytic transglycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lytic transglycosylase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidoglycan catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within peptidoglycan catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within peptidoglycan metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peptidoglycan turnover IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in outer membrane-bounded periplasmic space TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
membrane-bound lytic murein transglycosylase A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2946081..2947178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417293.1 membrane-bound lytic murein transglycosylase A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417293.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0A935
    Conserved Domains (1) summary
    PRK11162
    Location:1354
    mltA; murein transglycosylase A; Provisional