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panC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944958, updated on 11-Sep-2024

Summary

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Official Symbol
panC
Primary source
ECOCYC:EG11746
Locus tag
b0133
See related
ASAP:ABE-0000465
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0132
Summary
Pantothenate synthetase catalyzes the synthesis of pantothenate from -alanine and pantoate, requiring hydrolysis of ATP . [More information is available at EcoCyc: EG11746].
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Genomic context

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Sequence:
NC_000913.3 (147944..148795, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene aspartate 1-decarboxylase proenzyme Neighboring gene recombination-promoting nuclease RpnC Neighboring gene 3-methyl-2-oxobutanoate hydroxymethyltransferase Neighboring gene fimbrial tip-adhesin YadC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. B-vitamin nutrition in the pea aphid-Buchnera symbiosis. Blow F, et al. J Insect Physiol, 2020 Oct. PMID 32763248
  2. The design and synthesis of inhibitors of pantothenate synthetase. Tuck KL, et al. Org Biomol Chem, 2006 Oct 7. PMID 16990935
  3. NMR assignment of 2H, 13C and 15N labeled amino-terminal domain of apo-pantothenate synthetase from E. coli. Chakrabarti KS, et al. J Biomol NMR, 2006. PMID 16705359
  4. Synthesis of pantothenic acid by depyrophosphorylation of adenosine triphosphate. MAAS WK, et al. Arch Biochem Biophys, 1953 Mar. PMID 13031681
  5. Pantothenate studies. III. Description of the extracted pantothenate-synthesizing enzyme of Escherichia coli. MAAS WK. J Biol Chem, 1952 Sep. PMID 12999714

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. B-vitamin nutrition in the pea aphid-Buchnera symbiosis.
    Title: B-vitamin nutrition in the pea aphid-Buchnera symbiosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables pantoate-beta-alanine ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pantoate-beta-alanine ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pantoate-beta-alanine ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables pantoate-beta-alanine ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in pantothenate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pantothenate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pantothenate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
pantothenate synthetase
NP_414675.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    147944..148795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414675.1 pantothenate synthetase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414675.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9QA23
    Conserved Domains (1) summary
    PRK00380
    Location:1 → 283
    panC; pantoate--beta-alanine ligase; Reviewed
Nucleotide Protein
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