dinJ antitoxin/DNA-binding transcriptional repressor DinJ [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: dinJ
Official Full Name: antitoxin/DNA-binding transcriptional repressor DinJ
Primary source: ECOCYC:G6110
Locus tag: b0226
See related: ASAP:ABE-0000764
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0227; sosA
Summary: Coexpression of DinJ with YafQ blocks the growth inhibition of YafQ (Motiejunaite, 2007; Szekeres, 2007). [More information is available at EcoGene: EG13142]. The YafQ-DinJ toxin-antitoxin system was identified by its similarity to the RelE-RelB toxin-antitoxin system . [More information is available at EcoCyc: G6110].
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NC_000913.3 Genomic Context describing neighboring genes

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DinJ is involved in mediating the general stress response by indirect regulation of RpoS via its direct control of cspE
Title: Antitoxin DinJ influences the general stress response through transcript stabilizer CspE.
The endoribonuclease activity of YafQ was inhibited in the complex with DinJ antitoxin in vitro.
Title: Characterization of Escherichia coli dinJ-yafQ toxin-antitoxin system using insights from mutagenesis data.
acts as antitoxin in active toxin-antitoxin module with YafQ.
Title: Escherichia coli dinJ-yafQ genes act as a toxin-antitoxin module.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables toxic substance binding	IDA Inferred from Direct Assay more info	PubMed
enables toxic substance binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of growth	NAS Non-traceable Author Statement more info	PubMed
involved_in single-species biofilm formation	IDA Inferred from Direct Assay more info	PubMed
involved_in single-species biofilm formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within single-species biofilm formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of toxin-antitoxin complex	IPI Inferred from Physical Interaction more info	PubMed

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