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fabZ 3-hydroxy-acyl-[acyl-carrier-protein] dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944888, updated on 29-Sep-2023

Summary

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Gene symbol
fabZ
Gene description
3-hydroxy-acyl-[acyl-carrier-protein] dehydratase
Primary source
ASAP:ABE-0000613
Locus tag
b0180
See related
ECOCYC:EG11284
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0179; sabA1; sefA; sfhC21; yaeA
Summary
Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG11284]. Certain mutations in fabZ have been found as suppressor mutations; its sabA1 allele changes the suppression of the OmpF315 phenotype by asmB1, and increased fabZ expression suppresses OmpF315 itself . [More information is available at EcoCyc: EG11284].
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Genomic context

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Sequence:
NC_000913.3 (202101..202556)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene periplasmic chaperone Skp Neighboring gene UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase Neighboring gene acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase Neighboring gene lipid A disaccharide synthase Neighboring gene RNase HII

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An Escherichia coli gene (FabZ) encoding (3R)-hydroxymyristoyl acyl carrier protein dehydrase. Relation to fabA and suppression of mutations in lipid A biosynthesis. Mohan S, et al. J Biol Chem, 1994 Dec 30. PMID 7806516
  2. Septum formation-defective mutant of Escherichia coli. Normark S, et al. J Bacteriol, 1976 Oct. PMID 789345, Free PMC Article
  3. Fused dimerization increases expression, solubility, and activity of bacterial dehydratase enzymes. Rullán-Lind C, et al. Protein Sci, 2018 May. PMID 29520922, Free PMC Article
  4. Escherichia coli outer membrane phospholipase A: role of two serines in enzymatic activity. Brok RG, et al. Biochemistry, 1996 Jun 18. PMID 8672479
  5. A conserved histidine residue of Escherichia coli outer-membrane phospholipase A is important for activity. Brok RG, et al. Eur J Biochem, 1995 Dec 15. PMID 8575454

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The fused dimer of FabZ (FabZ-FabZ) was expressed as a soluble enzyme with an ninefold higher activity in vitro than the unfused FabZ.
    Title: Fused dimerization increases expression, solubility, and activity of bacterial dehydratase enzymes.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Purification and characterization of an 'actomyosin' complex from Escherichia coli W3110.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables (3R)-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables (3R)-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydro-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
3-hydroxy-acyl-[acyl-carrier-protein] dehydratase
NP_414722.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    202101..202556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414722.1 3-hydroxy-acyl-[acyl-carrier-protein] dehydratase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414722.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0A6Q6
    UniProtKB/TrEMBL
    A0A8S7GVI4
    Conserved Domains (1) summary
    PRK00006
    Location:2 → 150
    fabZ; 3-hydroxyacyl-ACP dehydratase FabZ
Nucleotide Protein
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Other Literature Sources
Molecular Biology Databases
Research Materials