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fabZ 3-hydroxy-acyl- [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944888, updated on 17-Jul-2025
Official Symbol
fabZ
Official Full Name
3-hydroxy-acyl-
Primary source
ECOCYC:EG11284
Locus tag
b0180
See related
ASAP:ABE-0000613
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0179; sabA1; sefA; sfhC21; yaeA
Summary
Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG11284]. Certain mutations in fabZ have been found as suppressor mutations; its sabA1 allele changes the suppression of the OmpF315 phenotype by asmB1, and increased fabZ expression suppresses OmpF315 itself . [More information is available at EcoCyc: EG11284].
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Sequence:
NC_000913.3 (202101..202556)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene periplasmic chaperone Skp Neighboring gene UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase Neighboring gene acyl- Neighboring gene lipid A disaccharide synthase Neighboring gene RNase HII

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Septum formation-defective mutant of Escherichia coli. Normark S, et al. J Bacteriol, 1976 Oct. PMID 789345, Free PMC Article
  2. An Escherichia coli gene (FabZ) encoding (3R)-hydroxymyristoyl acyl carrier protein dehydrase. Relation to fabA and suppression of mutations in lipid A biosynthesis. Mohan S, et al. J Biol Chem, 1994 Dec 30. PMID 7806516
  3. Insertion mutagenesis of the gene encoding the ferrichrome-iron receptor of Escherichia coli K-12. Carmel G, et al. J Bacteriol, 1990 Apr. PMID 2156805, Free PMC Article
  4. Induction of Escherichia coli hydroperoxidase I by acetate and other weak acids. Mukhopadhyay S, et al. J Bacteriol, 1994 Apr. PMID 8157598, Free PMC Article
  5. Molecular characterization of enterobacterial pldA genes encoding outer membrane phospholipase A. Brok RG, et al. J Bacteriol, 1994 Feb. PMID 8300539, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The fused dimer of FabZ (FabZ-FabZ) was expressed as a soluble enzyme with an ninefold higher activity in vitro than the unfused FabZ.
    Title: Fused dimerization increases expression, solubility, and activity of bacterial dehydratase enzymes.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Purification and characterization of an 'actomyosin' complex from Escherichia coli W3110.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
3-hydroxy-acyl-
NP_414722.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    202101..202556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414722.1 3-hydroxy-acyl-[acyl-carrier-protein] dehydratase

    See identical proteins and their annotated locations for NP_414722.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376U2X3
    Conserved Domains (1) summary
    PRK00006
    Location:2 → 150
    fabZ; 3-hydroxyacyl-ACP dehydratase FabZ
Nucleotide Protein
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