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hscA iron-sulfur cluster biosynthesis chaperone HscA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944885, updated on 4-Jun-2020

Summary

Gene symbol
hscA
Gene description
iron-sulfur cluster biosynthesis chaperone HscA
Primary source
EcoGene:EG12130
Locus tag
b2526
See related
ASAP:ABE-0008315; ECOCYC:EG12130
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2523; hsc
Summary
dnaK, hscA, hscC and yegD are paralogs. [More information is available at EcoGene: EG12130]. Hsc66 together with Hsc20 may comprise a chaperone system similar to DnaK/DnaJ . [More information is available at EcoCyc: EG12130].

Genomic context

Sequence:
NC_000913.3 (2657085..2658935, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene accessory iron-sulfur cluster assembly protein IscX Neighboring gene reduced ferredoxin Neighboring gene co-chaperone for [Fe-S] cluster biosynthesis Neighboring gene iron-sulfur cluster insertion protein IscA

Pathways from PubChem

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to cold IEP
Inferred from Expression Pattern
more info
PubMed 
iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
 
protein folding IEA
Inferred from Electronic Annotation
more info
 
protein maturation by iron-sulfur cluster transfer IDA
Inferred from Direct Assay
more info
PubMed 
protein maturation by iron-sulfur cluster transfer IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
iron-sulfur cluster transfer complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
iron-sulfur cluster biosynthesis chaperone HscA
NP_417021.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2657085..2658935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417021.1 iron-sulfur cluster biosynthesis chaperone HscA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417021.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0A6Z1
    Conserved Domains (1) summary
    PRK05183
    Location:1616
    hscA; chaperone protein HscA; Provisional
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