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hscA DnaK-like molecular chaperone specific for IscU [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944885, updated on 22-May-2018

Summary

Gene symbol
hscA
Gene description
DnaK-like molecular chaperone specific for IscU
Primary source
EcoGene:EG12130
Locus tag
b2526
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2523; hsc; JW2510
Summary
dnaK, hscA, hscC and yegD are paralogs. [More information is available at EcoGene: EG12130]. Hsc66 together with Hsc20 may comprise a chaperone system similar to DnaK/DnaJ . [More information is available at EcoCyc: EG12130].

Genomic context

Sequence:
NC_000913.3 (2657085..2658935, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene Fe(2+) donor and activity modulator for cysteine desulfurase Neighboring gene [2Fe-2S] ferredoxin Neighboring gene HscA co-chaperone, J domain-containing protein Hsc56; IscU-specific chaperone HscAB Neighboring gene FeS cluster assembly protein

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • [2Fe-2S] iron-sulfur cluster biosynthesis, conserved biosystem (from BIOCYC)
    [2Fe-2S] iron-sulfur cluster biosynthesis, conserved biosystemGeneral Background |FRAME: FeS-Centers "Iron-sulfur (Fe-S) clusters"| are cofators of |FRAME: FeS-Proteins "iron-sulfur proteins"| and consist of a cluster of two to four iron atoms linked to sulfid...

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity, coupled IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding involved in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular response to cold IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to heat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein maturation by iron-sulfur cluster transfer IDA
Inferred from Direct Assay
more info
PubMed 
protein maturation by iron-sulfur cluster transfer IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
iron-sulfur cluster transfer complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Names
DnaK-like molecular chaperone specific for IscU
NP_417021.1
  • DnaK-homologue chaperone Hsc66

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2657085..2658935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417021.1 DnaK-like molecular chaperone specific for IscU [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417021.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0A6Z1
    Conserved Domains (1) summary
    PRK05183
    Location:1616
    hscA; chaperone protein HscA; Provisional
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