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dnaE DNA polymerase III subunit alpha [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944877, updated on 6-May-2021

Summary

Gene symbol
dnaE
Gene description
DNA polymerase III subunit alpha
Primary source
ASAP:ABE-0000624
Locus tag
b0184
See related
ECOCYC:EG10238
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0183; polC; sdgC
Summary
Has a PHP domin, like YcdX. [More information is available at EcoGene: EG10238]. The alpha subunit of DNA polymerase III catalyzes the polymerase activity of the holoenzyme complex . [More information is available at EcoCyc: EG10238].
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Genomic context

Sequence:
NC_000913.3 (205126..208608)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase Neighboring gene lipid A disaccharide synthase Neighboring gene RNase HII Neighboring gene acetyl-CoA carboxyltransferase subunit alpha Neighboring gene lysine decarboxylase 2

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
NOT enables 3'-5' exonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of DNA polymerase III, core complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA polymerase III subunit alpha
NP_414726.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    205126..208608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414726.1 DNA polymerase III subunit alpha [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414726.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P10443
    Conserved Domains (1) summary
    PRK05673
    Location:51151
    dnaE; DNA polymerase III subunit alpha; Validated
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