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argP DNA-binding transcriptional dual regulator ArgP [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944867, updated on 3-Dec-2024

Summary

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Official Symbol
argP
Official Full Name
DNA-binding transcriptional dual regulator ArgP
Primary source
ECOCYC:EG10490
Locus tag
b2916
See related
ASAP:ABE-0009574
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2912; iciA
Summary
ArgP(IciA) is a LysR family transcriptional regulator. argP mutants are canavanine sensitive. argP is in the pho regulon. [More information is available at EcoGene: EG10490]. ArgP, "arginine protein," controls the transcription of genes involved in the arginine transport system and genes involved in DNA replication. [More information is available at EcoCyc: EG10490].
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Genomic context

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Sequence:
NC_000913.3 (3059753..3060646)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ribose-5-phosphate isomerase A Neighboring gene pseudo Neighboring gene methylmalonyl-CoA mutase Neighboring gene methylmalonyl-CoA mutase-interacting GTPase YgfD Neighboring gene methylmalonyl-CoA decarboxylase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Properties of an Escherichia coli K-12 mutant defective in the transport of arginine and ornithine. Celis TF. J Bacteriol, 1977 Jun. PMID 405374, Free PMC Article
  2. Interaction of the IciA protein with AT-rich regions in plasmid replication origins. Wei T, et al. Nucleic Acids Res, 1996 May 15. PMID 8657567, Free PMC Article
  3. Genetic defects affecting an arginine permease and repression of arginine synthesis in Escherichia coli. Maas WK. Fed Proc, 1965 Sep-Oct. PMID 5320107
  4. Basic amino acid transport in Escherichia coli. Rosen BP. J Biol Chem, 1971 Jun 10. PMID 4931309
  5. Analysis of the inhibition of growth produced by canavanine in Escherichia coli. SCHWARTZ JH, et al. J Bacteriol, 1960 Jun. PMID 14443992, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ArgP is a transcriptional regulator for lysine repression of genes and it is noncanonical in that it also exhibits low-affinity binding, without apparent direct regulatory effect, to a number of additional sites in the genome.
    Title: Role of ArgP (IciA) in lysine-mediated repression in Escherichia coli.
  2. These results indicate that ArgP is a major regulator of lysP expression but that Lrp modulates lysP transcription under lysine-limiting conditions.
    Title: Identification of ArgP and Lrp as transcriptional regulators of lysP, the gene encoding the specific lysine permease of Escherichia coli.
  3. Activation by Lrp interferes with the previously demonstrated activation of the argO promoter by ArgP.
    Title: Competitive activation of the Escherichia coli argO gene coding for an arginine exporter by the transcriptional regulators Lrp and ArgP.
  4. These results fit with a model in which ArgP contributes to enhanced transcription of dapB when lysine becomes limiting.
    Title: Lysine represses transcription of the Escherichia coli dapB gene by preventing its activation by the ArgP activator.
  5. The ArgP dimer by itself is able to bind the argO promoter-operator region to form a binary complex, but that the formation of a ternary complex with RNA polymerase is greatly stimulated only in presence of a coeffector.
    Title: Environmental regulation operating at the promoter clearance step of bacterial transcription.
  6. N-terminus verified by Edman degradation on complete protein
    Title: iciA, an Escherichia coli gene encoding a specific inhibitor of chromosomal initiation of replication in vitro.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables bent DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated DNA replication initiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator ArgP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3059753..3060646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417391.1 DNA-binding transcriptional dual regulator ArgP [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417391.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9Q9L8
    Conserved Domains (1) summary
    PRK03635
    Location:3 → 295
    PRK03635; ArgP/LysG family DNA-binding transcriptional regulator
Nucleotide Protein
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