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tsf protein chain elongation factor EF-Ts [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944866, updated on 4-Feb-2026
Official Symbol
tsf
Official Full Name
protein chain elongation factor EF-Ts
Primary source
ECOCYC:EG11033
Locus tag
b0170
See related
ASAP:ABE-0000579
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0169
Summary
Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG11033]. EF-Ts is an elongation factor associated with the ribosome; it functions as the guanine nucleotide exchange factor for the EF-Tu GTPase. [More information is available at EcoCyc: EG11033].
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Sequence:
NC_000913.3 (190857..191708)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene 30S ribosomal subunit protein S2 Neighboring gene UMP kinase Neighboring gene ribosome-recycling factor

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Kinetic studies on the interactions of Escherichia coli K12 elongation factor Tu with GDP and elongation factor Ts. Chau V, et al. J Biol Chem, 1981 Jun 10. PMID 7016856
  2. Qbeta-phage resistance by deletion of the coiled-coil motif in elongation factor Ts. Karring H, et al. J Biol Chem, 2004 Jan 16. PMID 14583631
  3. Elongation factors in protein biosynthesis. Andersen GR, et al. Trends Biochem Sci, 2003 Aug. PMID 12932732
  4. Kinetic mechanism of elongation factor Ts-catalyzed nucleotide exchange in elongation factor Tu. Gromadski KB, et al. Biochemistry, 2002 Jan 8. PMID 11772013
  5. Elongation factor Ts can act as a steric chaperone by increasing the solubility of nucleotide binding-impaired elongation factor-Tu. Krab IM, et al. Biochemistry, 2001 Jul 24. PMID 11456491

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. S2 functions as a negative regulator of both its own and tsf expression in vivo.
    Title: A new regulatory circuit in ribosomal protein operons: S2-mediated control of the rpsB-tsf expression in vivo.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: '98 Escherichia coli SWISS-2DPAGE database update.
  3. Tsf is identified as an aggregation-resistant protein through proteome-wide analysis in response to a protein denaturant.
    Title: Enhanced solubility of heterologous proteins by fusion expression using stress-induced Escherichia coli protein, Tsf.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
Preferred Names
protein chain elongation factor EF-Ts

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    190857..191708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414712.1 protein chain elongation factor EF-Ts

    See identical proteins and their annotated locations for NP_414712.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0M3KKV2
    Conserved Domains (1) summary
    PRK09377
    Location:1 → 281
    tsf; elongation factor Ts; Provisional
Nucleotide Protein
Heading Accession and Version

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