lplA lipoate--protein ligase A [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: lplA
Official Full Name: lipoate--protein ligase A
Primary source: ECOCYC:EG11796
Locus tag: b4386
See related: ASAP:ABE-0014385
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK4378; slr; yjjF
Summary: LplA first activates lipoic acid with ATP to form lipoyl-AMP. [More information is available at EcoGene: EG11796]. LplA is a lipoyl-protein ligase that preferentially utilizes lipoate imported from outside the cell, in contrast to the other lipoyl-protein ligase, LipB, which utilizes octanoyl-ACP . [More information is available at EcoCyc: EG11796].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Activation and competition of lipoylation of H protein and its hydrolysis in a reaction cascade catalyzed by the multifunctional enzyme lipoate-protein ligase A.
Title: Activation and competition of lipoylation of H protein and its hydrolysis in a reaction cascade catalyzed by the multifunctional enzyme lipoate-protein ligase A.
analysis of the conformational change associated with the two-step reaction catalyzed by Escherichia coli lipoate-protein ligase A
Title: Global conformational change associated with the two-step reaction catalyzed by Escherichia coli lipoate-protein ligase A.
N-terminus verified by Edman degradation on mature peptide
Title: Identification of the gene encoding lipoate-protein ligase A of Escherichia coli. Molecular cloning and characterization of the lplA gene and gene product.

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Function	Evidence Code	Pubs
enables lipoate-protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipoate-protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables lipoate-protein ligase activity	IEA Inferred from Electronic Annotation more info
enables lipoate-protein ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lipoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in protein lipoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein lipoylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein lipoylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed