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lpxB lipid A disaccharide synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944838, updated on 30-Jul-2025
Official Symbol
lpxB
Official Full Name
lipid A disaccharide synthase
Primary source
ECOCYC:EG10546
Locus tag
b0182
See related
ASAP:ABE-0000620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0181; pgsB
Summary
The lpxB1 mutation is E326K, the result of a change in codon 326 from GAA to AAA (C.R.H. [More information is available at EcoGene: EG10546]. Lipid A disaccharide synthase (LpxB) catalyzes the fifth step in lipid A biosynthesis. [More information is available at EcoCyc: EG10546].
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Sequence:
NC_000913.3 (203348..204496)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase Neighboring gene 3-hydroxy-acyl- Neighboring gene acyl- Neighboring gene RNase HII Neighboring gene DNA polymerase III subunit alpha Neighboring gene acetyl-CoA carboxyltransferase subunit alpha

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Membrane lipid biogenesis in Escherichia coli: identification of genetic loci for phosphatidylglycerophosphate synthetase and construction of mutants lacking phosphatidylglycerol. Nishijima M, et al. J Biol Chem, 1979 Aug 25. PMID 381294
  2. Purification and characterization of the lipid A disaccharide synthase (LpxB) from Escherichia coli, a peripheral membrane protein. Metzger LE 4th, et al. Biochemistry, 2009 Dec 8. PMID 19883124, Free PMC Article
  3. Lipid A disaccharide synthase from Escherichia coli. Raetz CR. Methods Enzymol, 1992. PMID 1495426
  4. Enzymatic synthesis and comparative biological evaluation of a phosphonate analogue of the lipid A precursor. Scholz D, et al. J Med Chem, 1992 May 29. PMID 1597857
  5. Purification and properties of lipid A disaccharide synthase of Escherichia coli. Radika K, et al. J Biol Chem, 1988 Oct 15. PMID 3049593

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystal structure of LpxB has been resolved.
    Title: Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Purification and properties of lipid A disaccharide synthase of Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid-A-disaccharide synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid-A-disaccharide synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid A biosynthetic process IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within lipid A biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extrinsic component of cytoplasmic side of plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in extrinsic component of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
lipid A disaccharide synthase
NP_414724.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    203348..204496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414724.1 lipid A disaccharide synthase

    See identical proteins and their annotated locations for NP_414724.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A830SHI5
    Conserved Domains (1) summary
    PRK00025
    Location:6 → 382
    lpxB; lipid-A-disaccharide synthase; Reviewed
Nucleotide Protein
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