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pdhR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944827, updated on 11-Sep-2024

Summary

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Official Symbol
pdhR
Primary source
ECOCYC:EG11088
Locus tag
b0113
See related
ASAP:ABE-0000394
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
aceC; ECK0112; genA; yacB
Summary
The N-terminus of overexpressed PdhR has been determined (Quail and Guest, 1995), indicating that the initial Met is removed. however, the native pdhR RBS was not used, so PdhR is not in the Verified Set, although this is probably the correct start. [More information is available at EcoGene: EG11088]. PdhR, "pyruvate dehydrogenase complex regulator," regulates genes involved in the pyruvate dehydrogenase complex . [More information is available at EcoCyc: EG11088].
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Genomic context

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Sequence:
NC_000913.3 (122092..122856)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 1,6-anhydro-N-acetylmuramoyl-L-alanine amidase Neighboring gene protein AmpE Neighboring gene aromatic amino acid:H(+) symporter AroP Neighboring gene pyruvate dehydrogenase E1 component Neighboring gene pyruvate dehydrogenase, E2 subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expanded roles of pyruvate-sensing PdhR in transcription regulation of the Escherichia coli K-12 genome: fatty acid catabolism and cell motility. Anzai T, et al. Microb Genom, 2020 Oct. PMID 32975502, Free PMC Article
  2. Purification, characterization and mode of action of PdhR, the transcriptional repressor of the pdhR-aceEF-lpd operon of Escherichia coli. Quail MA, et al. Mol Microbiol, 1995 Feb. PMID 7783622
  3. PdhR, the pyruvate dehydrogenase repressor, does not regulate lipoic acid synthesis. Feng Y, et al. Res Microbiol, 2014 Jul-Aug. PMID 24816490, Free PMC Article
  4. The pdhR-aceEF-lpd operon of Escherichia coli expresses the pyruvate dehydrogenase complex. Quail MA, et al. Mol Microbiol, 1994 Apr. PMID 8057842
  5. The pyruvate dehydrogenase complex of Escherichia coli K12. Nucleotide sequence encoding the pyruvate dehydrogenase component. Stephens PE, et al. Eur J Biochem, 1983 Jun 1. PMID 6343085

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expanded roles of pyruvate-sensing PdhR in transcription regulation of the Escherichia coli K-12 genome: fatty acid catabolism and cell motility.
    Title: Expanded roles of pyruvate-sensing PdhR in transcription regulation of the Escherichia coli K-12 genome: fatty acid catabolism and cell motility.
  2. These data show that PdhR plays no physiological role in regulation of lipA expression.
    Title: PdhR, the pyruvate dehydrogenase repressor, does not regulate lipoic acid synthesis.
  3. Study suggests that PdhR is a master regulator for controlling the formation of not only the PDH complex but also the respiratory electron transport system.
    Title: PdhR (pyruvate dehydrogenase complex regulator) controls the respiratory electron transport system in Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator PdhR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    122092..122856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414655.1 DNA-binding transcriptional dual regulator PdhR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414655.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A826J305
    Conserved Domains (1) summary
    PRK09464
    Location:1 → 234
    pdhR; pyruvate dehydrogenase complex transcriptional repressor PdhR
Nucleotide Protein
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