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gpt xanthine-guanine phsophoribosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944817, updated on 26-Mar-2025
Official Symbol
gpt
Official Full Name
xanthine-guanine phsophoribosyltransferase
Primary source
ECOCYC:EG10414
Locus tag
b0238
See related
ASAP:ABE-0000814
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0239; glyD; gpp; gxu
Summary
Xanthine-guanine phosphoribosyltransferase is a purine salvage enzyme which converts either xanthine or guanine to XMP or GMP, respectively. [More information is available at EcoCyc: EG10414].
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Sequence:
NC_000913.3 (255977..256435)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene peptidase D Neighboring gene fermentation-respiration switch protein Neighboring gene IS1 family transposase B Neighboring gene pseudo Neighboring gene IS1 family repressor TnpA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Factors governing the expression of a bacterial gene in mammalian cells. Mulligan RC, et al. Mol Cell Biol, 1981 May. PMID 6100966, Free PMC Article
  2. Nucleotide sequence and analysis of deletion mutants of the Escherichia coli gpt gene in plasmid pSV2 gpt. Jagadeeswaran P, et al. Gene, 1984 Nov. PMID 6396164
  3. Mechanism of adenine toxicity in Escherichia coli. Levine RA, et al. J Bacteriol, 1982 Mar. PMID 6801015, Free PMC Article
  4. Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase. Mulligan RC, et al. Proc Natl Acad Sci U S A, 1981 Apr. PMID 7017722, Free PMC Article
  5. Crystallization and preliminary X-ray crystallographic studies of Escherichia coli xanthine phosphoribosyltransferase. Vos S, et al. J Struct Biol, 1996 Mar-Apr. PMID 8812991

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Report chemical structure-related mechanisms underlying in vivo genotoxicity induced by nitrofurantoin and its constituent moieties in gpt delta rats.
    Title: Chemical structure-related mechanisms underlying in vivo genotoxicity induced by nitrofurantoin and its constituent moieties in gpt delta rats.
  2. Data suggest that arsenite induces guanine phosphoribosyltransferase gpt G:C to T:A transversions through oxidative-stress-induced 8-OHdG formation.
    Title: In vivo mutagenicity of arsenite in the livers of gpt delta transgenic mice.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanine phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanosine tetraphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables hypoxanthine phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hypoxanthine phosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hypoxanthine phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables xanthine phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables xanthine phosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables xanthine phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GMP salvage IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within GMP salvage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in IMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within IMP salvage IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in XMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in XMP salvage IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within XMP salvage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in purine ribonucleoside salvage IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
xanthine-guanine phsophoribosyltransferase
NP_414773.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    255977..256435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414773.1 xanthine-guanine phsophoribosyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414773.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7K443
    Conserved Domains (1) summary
    PRK09177
    Location:1 → 152
    PRK09177; xanthine-guanine phosphoribosyltransferase; Validated
Nucleotide Protein
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