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gpt xanthine-guanine phsophoribosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944817, updated on 2-May-2024

Summary

Gene symbol
gpt
Gene description
xanthine-guanine phsophoribosyltransferase
Primary source
ASAP:ABE-0000814
Locus tag
b0238
See related
ECOCYC:EG10414
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0239; glyD; gpp; gxu
Summary
Xanthine-guanine phosphoribosyltransferase is a purine salvage enzyme which converts either xanthine or guanine to XMP or GMP, respectively. [More information is available at EcoCyc: EG10414].
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Genomic context

Sequence:
NC_000913.3 (255977..256435)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene peptidase D Neighboring gene fermentation-respiration switch protein Neighboring gene IS1 family transposase B Neighboring gene pseudo Neighboring gene IS1 family repressor TnpA

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables guanine phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables guanosine tetraphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hypoxanthine phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hypoxanthine phosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hypoxanthine phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables xanthine phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables xanthine phosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables xanthine phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in GMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in GMP salvage IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within GMP salvage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in IMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within IMP salvage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in XMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in XMP salvage IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within XMP salvage IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in purine ribonucleoside salvage IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
xanthine-guanine phsophoribosyltransferase
NP_414773.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    255977..256435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414773.1 xanthine-guanine phsophoribosyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414773.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AA39
    Conserved Domains (1) summary
    PRK09177
    Location:1152
    PRK09177; xanthine-guanine phosphoribosyltransferase; Validated