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mraZ DNA-binding transcriptional repressor MraZ [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944810, updated on 30-Jul-2025
Official Symbol
mraZ
Official Full Name
DNA-binding transcriptional repressor MraZ
Primary source
ECOCYC:EG11084
Locus tag
b0081
See related
ASAP:ABE-0000302
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0082; yabB
Summary
The MraZ protein is highly conserved in bacteria, but its function has not yet been determined. [More information is available at EcoCyc: EG11084].
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Sequence:
NC_000913.3 (89634..90092)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene acetolactate synthase/acetohydroxybutanoate synthase, regulatory subunit Neighboring gene DNA-binding transcriptional regulator Cra Neighboring gene 16S rRNA m(4)C1402 methyltransferase Neighboring gene cell division protein FtsL Neighboring gene peptidoglycan DD-transpeptidase FtsI Neighboring gene ncRNA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. MraZ from Escherichia coli: cloning, purification, crystallization and preliminary X-ray analysis. Adams MA, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Apr 1. PMID 16511046, Free PMC Article
  2. Escherichia coli Proteome Microarrays Identified the Substrates of ClpYQ Protease. Tsai CH, et al. Mol Cell Proteomics, 2017 Jan. PMID 27864322, Free PMC Article
  3. AbrB-like transcription factors assume a swapped hairpin fold that is evolutionarily related to double-psi beta barrels. Coles M, et al. Structure, 2005 Jun. PMID 15939023
  4. Nucleotide sequence of the regulatory region of the gene pbpB of Escherichia coli. Gómez MJ, et al. Nucleic Acids Res, 1990 May 11. PMID 2187182, Free PMC Article
  5. Proteomics of Mycoplasma genitalium: identification and characterization of unannotated and atypical proteins in a small model genome. Balasubramanian S, et al. Nucleic Acids Res, 2000 Aug 15. PMID 10931922, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results provide evidence that YbaB is a novel substrate of ClpYQ protease through its binding to ClpY subunit.
    Title: Escherichia coli Proteome Microarrays Identified the Substrates of ClpYQ Protease.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoid IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA-binding transcriptional repressor MraZ

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    89634..90092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414623.1 DNA-binding transcriptional repressor MraZ

    See identical proteins and their annotated locations for NP_414623.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2X1MMA9
    Conserved Domains (1) summary
    TIGR00242
    Location:1 → 151
    TIGR00242; division/cell wall cluster transcriptional repressor MraZ
Nucleotide Protein
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Other Literature Sources
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Research Materials