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cra DNA-binding transcriptional regulator Cra [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944804, updated on 6-Jul-2026
Official Symbol
cra
Official Full Name
DNA-binding transcriptional regulator Cra
Primary source
ECOCYC:EG10338
Locus tag
b0080
See related
ASAP:ABE-0000299
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0081; fruC; fruR; shl
Summary
FruR is a dual transcriptional regulator implicated in the regulation of a large number of operons that encode enzymes which comprise central pathways of carbon metabolism. [More information is available at EcoCyc: EG10338].
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Sequence:
NC_000913.3 (88028..89032)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene acetolactate synthase/acetohydroxybutanoate synthase, catalytic subunit Neighboring gene acetolactate synthase/acetohydroxybutanoate synthase, regulatory subunit Neighboring gene DNA-binding transcriptional repressor MraZ Neighboring gene 16S rRNA m(4)C1402 methyltransferase Neighboring gene cell division protein FtsL

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A novel mutation FruS, altering synthesis of components of the phosphoenolpyruvate: fructose phosphotransferase system in Escherichia coli K12. Bolshakova TN, et al. Mol Gen Genet, 1992 Apr. PMID 1534139
  2. Three-dimensional structure of the DNA-binding domain of the fructose repressor from Escherichia coli by 1H and 15N NMR. Penin F, et al. J Mol Biol, 1997 Jul 18. PMID 9237914
  3. Cra and the control of carbon flux via metabolic pathways. Ramseier TM. Res Microbiol, 1996 Jul-Sep. PMID 9084760
  4. Cyclic AMP-independent catabolite repression in bacteria. Saier MH Jr. FEMS Microbiol Lett, 1996 May 1. PMID 9026456
  5. Definition of a consensus DNA-binding site for the Escherichia coli pleiotropic regulatory protein, FruR. Nègre D, et al. Mol Microbiol, 1996 Jul. PMID 8858581

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that DNA-binding transcriptional dual regulators Cra and CRP are most active on poor carbon sources.
    Title: Systems assessment of transcriptional regulation on central carbon metabolism by Cra and CRP.
  2. Authors show that Cra regulates growth by activating expression of the crp gene.
    Title: Regulation of crp gene expression by the catabolite repressor/activator, Cra, in Escherichia coli.
  3. The deletion of cra and kdpE resulted in the ablation of attaching and effacing lesions.
    Title: Virulence meets metabolism: Cra and KdpE gene regulation in enterohemorrhagic Escherichia coli.
  4. Curli biosynthesis is regulated by Cra. Cra mutants are inpaired in iofilm formation.
    Title: Biofilm formation in Escherichia coli cra mutants is impaired due to down-regulation of curli biosynthesis.
  5. Two lines of evidence indicate that a total of as many as 178 promoters are under the control of Cra.
    Title: Novel members of the Cra regulon involved in carbon metabolism in Escherichia coli.
  6. The glucose uptake rate and the acetate production rate were increased with less acetate consumption for the cra mutant.
    Title: Effect of cra gene knockout together with edd and iclR genes knockout on the metabolism in Escherichia coli.
  7. Identified as new member of the polyamine modulon together with RpoN and H-NS.
    Title: Enhancement of the synthesis of RpoN, Cra, and H-NS by polyamines at the level of translation in Escherichia coli cultured with glucose and glutamate.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to fructose IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA-binding transcriptional regulator Cra

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    88028..89032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414622.1 DNA-binding transcriptional regulator Cra

    See identical proteins and their annotated locations for NP_414622.1

    Status: REVIEWED

    Conserved Domains (1) summary
    PRK11303
    Location:1 → 328
    PRK11303; catabolite repressor/activator
Nucleotide Protein
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