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murE UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944791, updated on 25-Jun-2025
Official Symbol
murE
Official Full Name
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
Primary source
ECOCYC:EG10621
Locus tag
b0085
See related
ASAP:ABE-0000311
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0086
Summary
A carbamylated lysine residue is present in the active site. [More information is available at EcoGene: EG10621].
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Sequence:
NC_000913.3 (93166..94653)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 16S rRNA m(4)C1402 methyltransferase Neighboring gene cell division protein FtsL Neighboring gene peptidoglycan DD-transpeptidase FtsI Neighboring gene ncRNA Neighboring gene D-alanyl-D-alanine-adding enzyme Neighboring gene phospho-N-acetylmuramoyl-pentapeptide-transferase Neighboring gene UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase Neighboring gene peptidoglycan glycosyltransferase FtsW

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Over-production, purification and properties of the uridine-diphosphate-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-2,6-diaminopimelate ligase from Escherichia coli. Michaud C, et al. Eur J Biochem, 1990 Dec 27. PMID 2269304
  2. Nucleotide sequence of the murE gene of Escherichia coli. Tao JS, et al. Can J Microbiol, 1989 Nov. PMID 2692800
  3. Specificity of the uridine-diphosphate-N-acetylmuramyl-L-alanyl-D-glutamate: meso-2,6-diaminopimelate synthetase from Escherichia coli. Abo-Ghalia M, et al. Eur J Biochem, 1985 Nov 15. PMID 3905407
  4. Temperature-sensitive mutants of Escherichia coli K-12 with low activity of the diaminopimelic acid adding enzyme. Lugtenberg EJ, et al. J Bacteriol, 1972 Apr. PMID 4553000, Free PMC Article
  5. Replacement of diaminopimelic acid by cystathionine or lanthionine in the peptidoglycan of Escherichia coli. Mengin-Lecreulx D, et al. J Bacteriol, 1994 Jul. PMID 8021219, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Over-production, purification and properties of the uridine-diphosphate-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-2,6-diaminopimelate ligase from Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acid-amino acid ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
NP_414627.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    93166..94653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414627.1 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414627.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T5ZWY2
    Conserved Domains (1) summary
    PRK00139
    Location:1 → 494
    murE; UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Nucleotide Protein
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