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folA dihydrofolate reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944790, updated on 9-Mar-2022

Summary

Gene symbol
folA
Gene description
dihydrofolate reductase
Primary source
ASAP:ABE-0000164
Locus tag
b0048
See related
ECOCYC:EG10326
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0049; tmr; tmrA
Summary
folA is an essential gene. [More information is available at EcoGene: EG10326]. Dihydrofolate reductase catalyzes the reduction of dihydrofolate to tetrahydrofolate, which is an important intermediate in the biosynthesis of proteins and nucleic acids . [More information is available at EcoCyc: EG10326].
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Genomic context

Sequence:
NC_000913.3 (49823..50302)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter YaaU Neighboring gene regulator of KefC-mediated potassium transport and quinone oxidoreductase Neighboring gene K(+) : H(+) antiporter KefC Neighboring gene diadenosine tetraphosphatase Neighboring gene DUF525 domain-containing protein ApaG

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables NADP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 
enables NADP+ binding IDA
Inferred from Direct Assay
more info
PubMed 
enables NADP+ binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NADPH binding IDA
Inferred from Direct Assay
more info
PubMed 
enables NADPH binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables dihydrofolate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dihydrofolate reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables dihydrofolate reductase activity IEA
Inferred from Electronic Annotation
more info
 
enables dihydrofolate reductase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables dihydrofolic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables folic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables folic acid binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables methotrexate binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dihydrofolate reductase
NP_414590.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    49823..50302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414590.1 dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414590.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0ABQ4
    Conserved Domains (1) summary
    PRK10769
    Location:1159
    folA; type 3 dihydrofolate reductase