ftsA cell division protein FtsA [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: ftsA
Official Full Name: cell division protein FtsA
Primary source: ECOCYC:EG10339
Locus tag: b0094
See related: ASAP:ABE-0000331
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: divA; ECK0095
Summary: FtsA is an essential gene. ftsA* mutants no longer require zipA. [More information is available at EcoGene: EG10339]. FtsA is an essential cell division protein which colocalizes with FtsZ to the septal ring structure; localization is FtsZ-dependent . [More information is available at EcoCyc: EG10339].
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Genomic context

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Sequence:: NC_000913.3 (103982..105244)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Construction and Characterization of Functional FtsA Sandwich Fusions for Studies of FtsA Localization and Dynamics during Escherichia coli Cell Division.
Title: Construction and Characterization of Functional FtsA Sandwich Fusions for Studies of FtsA Localization and Dynamics during Escherichia coli Cell Division.
Min waves without MinC can pattern FtsA-anchored FtsZ filaments on model membranes.
Title: Min waves without MinC can pattern FtsA-anchored FtsZ filaments on model membranes.
Roles of ATP Hydrolysis by FtsEX and Interaction with FtsA in Regulation of Septal Peptidoglycan Synthesis and Hydrolysis.
Title: Roles of ATP Hydrolysis by FtsEX and Interaction with FtsA in Regulation of Septal Peptidoglycan Synthesis and Hydrolysis.
SAXSDom: Modeling multidomain protein structures using small-angle X-ray scattering data.
Title: SAXSDom: Modeling multidomain protein structures using small-angle X-ray scattering data.
Protein interaction of FtsK with FTsA is essential to cell division.
Title: FtsA G50E mutant suppresses the essential requirement for FtsK during bacterial cell division in Escherichia coli.
FtsEX first interacts with FtsZ to localize to the Z ring and then interacts with FtsA to promote divisome assembly and regulate septal peptidoglycan synthesis.
Title: How FtsEX localizes to the Z ring and interacts with FtsA to regulate cell division.
Here, the authors use in vivo cross-linking to show that FtsA and ZipA indeed interact directly. They identify the exposed surface of FtsA helix 7, which also participates in binding to ATP through its internal surface, as a key interface needed for the interaction with ZipA.
Title: Direct Interaction between the Two Z Ring Membrane Anchors FtsA and ZipA.
Conversion of FtsA minirings into any type of non-miniring oligomer can promote progression of cytokinesis through FtsZ bundling and other mechanisms.
Title: Gain-of-function variants of FtsA form diverse oligomeric structures on lipids and enhance FtsZ protofilament bundling.
FtsA minirings appear to guide FtsZ to form long, often parallel, but unbundled protofilaments.
Title: Escherichia coli FtsA forms lipid-bound minirings that antagonize lateral interactions between FtsZ protofilaments.
These results implicate the actin homolog FtsA in establishment of a Z-ring scaffold, while directly remodeling the membrane and provide mechanistic insight into localized cell wall remodeling, invagination and constriction at the onset of division.
Title: FtsA reshapes membrane architecture and remodels the Z-ring in Escherichia coli.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in FtsZ-dependent cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in FtsZ-dependent cytokinesis	NAS Non-traceable Author Statement more info	PubMed
involved_in cell division	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	NAS Non-traceable Author Statement more info	PubMed
involved_in division septum assembly	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
located_in cell division site	IDA Inferred from Direct Assay more info	PubMed
located_in cell division site	IEA Inferred from Electronic Annotation more info
located_in cell division site	NAS Non-traceable Author Statement more info	PubMed
is_active_in cytoplasmic side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of divisome complex	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: cell division protein FtsA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

103982..105244

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_414636.1 cell division protein FtsA [Escherichia coli str. K-12 substr. MG1655]

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A418GG54, A0A5B9APS2, A0A5D8ML14, A0A8S7BTW0

Conserved Domains (1) summary

PRK09472
Location:1 → 420

ftsA; cell division protein FtsA; Reviewed