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kefC K(+) : H(+) antiporter KefC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944773, updated on 4-Feb-2026
Official Symbol
kefC
Official Full Name
K(+) : H(+) antiporter KefC
Primary source
ECOCYC:EG10521
Locus tag
b0047
See related
ASAP:ABE-0000161
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0048; trkC
Summary
KefB and KefC are two independent glutathione-regulated potassium efflux systems, which play a role in protecting the cell from electrophile toxicity. [More information is available at EcoCyc: EG10521].
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Sequence:
NC_000913.3 (47769..49631)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative oxidoreductase FixC Neighboring gene putative ferredoxin FixX Neighboring gene putative transporter YaaU Neighboring gene regulator of KefC-mediated potassium transport and quinone oxidoreductase Neighboring gene dihydrofolate reductase Neighboring gene diadenosine tetraphosphatase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structure and mechanism of the K(+)/H(+) exchanger KefC. Gulati A, et al. Nat Commun, 2024 Jun 4. PMID 38834573, Free PMC Article
  2. The putative Na+/H+ antiporter (NapA) of Enterococcus hirae is homologous to the putative K+/H+ antiporter (KefC) of Escherichia coli. Reizer J, et al. FEMS Microbiol Lett, 1992 Jul 1. PMID 1325937
  3. The distribution of homologues of the Escherichia coli KefC K(+)-efflux system in other bacterial species. Douglas RM, et al. J Gen Microbiol, 1991 Aug. PMID 1955875
  4. The K(+)-efflux system, KefC, in Escherichia coli: genetic evidence for oligomeric structure. Douglas RM, et al. Mol Membr Biol, 1994 Jan-Mar. PMID 8019602
  5. Nucleotide sequence of the E coli gene coding for dihydrofolate reductase. Smith DR, et al. Nucleic Acids Res, 1980 May 24. PMID 6159575, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure and mechanism of the K[+]/H[+] exchanger KefC.
    Title: Structure and mechanism of the K(+)/H(+) exchanger KefC.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glutathione-regulated potassium exporter activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione-regulated potassium exporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables toxic substance binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables toxic substance binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular pH elevation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within potassium ion transport EXP
Inferred from Experiment
more info
 PubMed 
involved_in potassium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within potassium ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of pH IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to methylglyoxal IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to methylglyoxal IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to toxic substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
K(+) : H(+) antiporter KefC

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    47769..49631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414589.1 K(+) : H(+) antiporter KefC

    See identical proteins and their annotated locations for NP_414589.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376FQ59, A0A6M9X2P6
    Conserved Domains (1) summary
    PRK03562
    Location:1 → 620
    PRK03562; glutathione-regulated potassium-efflux system protein KefC; Provisional
Nucleotide Protein
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