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kefC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944773, updated on 24-Aug-2024

Summary

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Official Symbol
kefC
Primary source
ECOCYC:EG10521
Locus tag
b0047
See related
ASAP:ABE-0000161
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0048; trkC
Summary
KefB and KefC are two independent glutathione-regulated potassium efflux systems, which play a role in protecting the cell from electrophile toxicity. [More information is available at EcoCyc: EG10521].
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Genomic context

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Sequence:
NC_000913.3 (47769..49631)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative oxidoreductase FixC Neighboring gene putative ferredoxin FixX Neighboring gene putative transporter YaaU Neighboring gene regulator of KefC-mediated potassium transport and quinone oxidoreductase Neighboring gene dihydrofolate reductase Neighboring gene diadenosine tetraphosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The K(+)-efflux system, KefC, in Escherichia coli: genetic evidence for oligomeric structure. Douglas RM, et al. Mol Membr Biol, 1994 Jan-Mar. PMID 8019602
  2. The distribution of homologues of the Escherichia coli KefC K(+)-efflux system in other bacterial species. Douglas RM, et al. J Gen Microbiol, 1991 Aug. PMID 1955875
  3. The putative Na+/H+ antiporter (NapA) of Enterococcus hirae is homologous to the putative K+/H+ antiporter (KefC) of Escherichia coli. Reizer J, et al. FEMS Microbiol Lett, 1992 Jul 1. PMID 1325937
  4. KTN (RCK) domains regulate K+ channels and transporters by controlling the dimer-hinge conformation. Roosild TP, et al. Structure, 2009 Jun 10. PMID 19523906, Free PMC Article
  5. Different foci for the regulation of the activity of the KefB and KefC glutathione-gated K+ efflux systems. Ness LS, et al. J Biol Chem, 1999 Apr 2. PMID 10092637

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure and mechanism of the K[+]/H[+] exchanger KefC.
    Title: Structure and mechanism of the K(+)/H(+) exchanger KefC.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glutathione-regulated potassium exporter activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione-regulated potassium exporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables toxic substance binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables toxic substance binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular pH elevation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within potassium ion transport EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within potassium ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of pH IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to methylglyoxal IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to methylglyoxal IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to toxic substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of potassium:proton antiporter complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
K(+) : H(+) antiporter KefC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    47769..49631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414589.1 K(+) : H(+) antiporter KefC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414589.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376FQ59, A0A6M9X2P6
    Conserved Domains (1) summary
    PRK03562
    Location:1 → 620
    PRK03562; glutathione-regulated potassium-efflux system protein KefC; Provisional
Nucleotide Protein
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