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mhpD 2-hydroxypentadienoate hydratase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944768, updated on 30-Jul-2025
Official Symbol
mhpD
Official Full Name
2-hydroxypentadienoate hydratase
Primary source
ECOCYC:M013
Locus tag
b0350
See related
ASAP:ABE-0001205
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0347; mhpS
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Sequence:
NC_000913.3 (372115..372924)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-carboxyethylcatechol 2,3-dioxygenase Neighboring gene 2-hydroxy-6-ketonona-2,4-dienedioate hydrolase Neighboring gene acetaldehyde dehydrogenase (acetylating) MhpF Neighboring gene 4-hydroxy-2-oxovalerate aldolase Neighboring gene 3-hydroxyphenylpropionate/3-hydroxycinnamate:H(+) symporter

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Assembly of a 20-nm protein cage by Escherichia coli 2-hydroxypentadienoic acid hydratase. Montgomery MG, et al. J Mol Biol, 2010 Mar 12. PMID 20053352
  2. Overproduction, purification and properties of 2,3-dihydroxyphenylpropionate 1,2-dioxygenase from Escherichia coli. Bugg TD. Biochim Biophys Acta, 1993 Oct 6. PMID 8399388
  3. Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli. Burlingame R, et al. J Bacteriol, 1983 Jul. PMID 6345502, Free PMC Article
  4. Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation. Burlingame RP, et al. J Bacteriol, 1986 Oct. PMID 3531186, Free PMC Article
  5. Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12. Ferrández A, et al. J Bacteriol, 1997 Apr. PMID 9098055, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pentameric 2-hydroxypentadienoic acid hydratase assembles to form a 20-nm-diameter particle comprising 60 protein subunits, arranged with 532 symmetry when crystallised at low pH in the presence of phosphate or sulphate ions.
    Title: Assembly of a 20-nm protein cage by Escherichia coli 2-hydroxypentadienoic acid hydratase.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Purification, characterisation and reaction mechanism of monofunctional 2-hydroxypentadienoic acid hydratase from Escherichia coli.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2-oxopent-4-enoate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2-oxopent-4-enoate hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2-oxopent-4-enoate hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 3-phenylpropionate catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
2-hydroxypentadienoate hydratase
NP_414884.2

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    372115..372924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414884.2 2-hydroxypentadienoate hydratase

    See identical proteins and their annotated locations for NP_414884.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1X3JM23
    Conserved Domains (1) summary
    PRK11342
    Location:1 → 262
    mhpD; 2-keto-4-pentenoate hydratase; Provisional
Nucleotide Protein
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