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C capsid protein;pre-capsid protein [ Hepatitis B virus ]

Gene ID: 944568, updated on 18-Jul-2024
Gene symbol
C
Gene description
capsid protein;pre-capsid protein
Locus tag
HBVgp4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Hepatitis B virus (strain: ayw)
Lineage
Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Blubervirales; Hepadnaviridae; Orthohepadnavirus
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Sequence:
NC_003977.2 (1816..2454)

NC_003977.2Genomic Context describing neighboring genes Neighboring gene large envelope protein;middle envelope protein;small envelope protein Neighboring gene polymerase Neighboring gene X protein Neighboring gene polymerase Neighboring gene large envelope protein;middle envelope protein;small envelope protein

Genomic Sequence:
NC_003977.2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Hepatitis B virus nucleocapsid but not free core antigen controls viral clearance in mice. Lin YJ, et al. J Virol, 2012 Sep. PMID 22718814, Free PMC Article
  2. Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients. Utama A, et al. World J Gastroenterol, 2011 Feb 14. PMID 21390140, Free PMC Article
  3. Precore and core promoter mutations of the hepatitis B virus gene in chronic genotype C-infected children. Kang HS, et al. J Korean Med Sci, 2011 Apr. PMID 21468263, Free PMC Article
  4. Molecular and serological characterization of occult hepatitis B infection in blood donors from Mexico. García-Montalvo BM, et al. Ann Hepatol, 2011 Apr-Jun. PMID 21502674
  5. HBc binds to the CpG islands of HBV cccDNA and promotes an epigenetic permissive state. Guo YH, et al. Epigenetics, 2011 Jun. PMID 21546797

See all (139) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATM-Dependent Phosphorylation of Hepatitis B Core Protein in Response to Genotoxic Stress.
    Title: ATM-Dependent Phosphorylation of Hepatitis B Core Protein in Response to Genotoxic Stress.
  2. A Pleiotropic Role of the Hepatitis B Virus Core Protein in Hepatocarcinogenesis.
    Title: A Pleiotropic Role of the Hepatitis B Virus Core Protein in Hepatocarcinogenesis.
  3. In vitro expression of precore proteins of hepatitis B virus subgenotype A1 is affected by HBcAg, and can affect HBsAg secretion.
    Title: In vitro expression of precore proteins of hepatitis B virus subgenotype A1 is affected by HBcAg, and can affect HBsAg secretion.
  4. Regulation of Hepatitis B Virus Replication by Cyclin Docking Motifs in Core Protein.
    Title: Regulation of Hepatitis B Virus Replication by Cyclin Docking Motifs in Core Protein.
  5. Conservation and variability of hepatitis B core at different chronic hepatitis stages.
    Title: Conservation and variability of hepatitis B core at different chronic hepatitis stages.
  6. The binding between HBc and BAF200 was of vital importance to HBc mediated downregulation of interferon-induced transmembrane protein 1 (IFITM1) expression.
    Title: Human Hepatitis B Virus Core Protein Inhibits IFNα-Induced IFITM1 Expression by Interacting with BAF200.
  7. Hepatitis B virus core antigen, but not open reading frame C proteins, promoted lipopolysaccharide-induced NLRP3 inflammasome activation and IL-1beta production.
    Title: Hepatitis B core antigen can regulate NLRP3 inflammasome pathway in HepG2 cells.
  8. Thus, hyperactive status of B cells in patients with chronic hepatitis B infection could be partially derived from the higher 4-1BBL expression on B cells triggered by HBcAg
    Title: HBcAg-induced upregulated 4-1BB ligand on B cells contributes to B-cell hyperactivation during chronic hepatitis B infection.
  9. Study found that HBeAg can associate with NEMO, the regulatory subunit for IkappaB kinase (IKK) that controls the NF-kappaB signaling pathway, and thereby inhibits TRAF6-mediated K63-linked ubiquitination of NEMO, resulting in downregulation of NF-kappaB activity and promotion of virus replication.
    Title: Hepatitis B e Antigen Inhibits NF-κB Activity by Interrupting K63-Linked Ubiquitination of NEMO.
  10. Results show that there is no significant increase in number of mutations in the core gene of the virus during the anti-HBe positive period.
    Title: Mutations in Core Gene Region of Hepatitis B Virus in Patients with Chronic Hepatitis B.
Submit: New GeneRIF Correction See all GeneRIFs (136)

regulatory

  • Loc: 1826-1836
  • Loc: 1834-1839
  • Loc: 1849-1909
Preferred Names
capsid protein;pre-capsid protein
YP_009173857.1
  • precursor

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003977.2 Reference assembly

    Range
    1816..2454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009173857.1 pre-capsid protein [Hepatitis B virus]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0C573
    UniProtKB/TrEMBL
    A0A679DL05, E5RPK6, Q89656, W0JGT6

  2. YP_009173868.3 capsid protein [Hepatitis B virus]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03146
    UniProtKB/TrEMBL
    A0A679DQ48, A0A679FH63, Q1T7C4, Q6XJX9, Q778I9, W0JCF4
Nucleotide Protein
Heading Accession and Version

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