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MED17 mediator complex subunit 17 [ Homo sapiens (human) ]

Gene ID: 9440, updated on 5-Jul-2020

Summary

Official Symbol
MED17provided by HGNC
Official Full Name
mediator complex subunit 17provided by HGNC
Primary source
HGNC:HGNC:2375
See related
Ensembl:ENSG00000042429 MIM:603810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRB4; CRSP6; CRSP77; DRIP80; TRAP80
Summary
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 8.7), ovary (RPKM 8.2) and 25 other tissues See more
Orthologs

Genomic context

See MED17 in Genome Data Viewer
Location:
11q21
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (93784282..93814963)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (93517405..93546496)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 40 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I subunit D Neighboring gene chromosome 11 open reading frame 54 Neighboring gene Sharpr-MPRA regulatory region 5970 Neighboring gene V-set and transmembrane domain containing 5 Neighboring gene uncharacterized LOC101060084

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mediator complex subunit 17 (MED17) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Knockdown of MED17 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10812

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nuclear receptor transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
nuclear receptor transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coregulator activity IDA
Inferred from Direct Assay
more info
PubMed 
vitamin D receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 17
Names
ARC77
CRSP complex subunit 6
activator-recruited cofactor 77 kDa component
cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa
epididymis secretory sperm binding protein
thyroid hormone receptor-associated protein complex 80 kDa component
transcriptional coactivator CRSP77
vitamin D3 receptor-interacting protein complex 80 kDa component

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028028.1 RefSeqGene

    Range
    5044..35725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004268.5NP_004259.3  mediator of RNA polymerase II transcription subunit 17

    See identical proteins and their annotated locations for NP_004259.3

    Status: REVIEWED

    Source sequence(s)
    AK001674, AP001894, DA506467
    Consensus CDS
    CCDS8295.1
    UniProtKB/Swiss-Prot
    Q9NVC6
    Related
    ENSP00000251871.3, ENST00000251871.9
    Conserved Domains (1) summary
    pfam10156
    Location:125398
    Med17; Subunit 17 of Mediator complex

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    93784282..93814963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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