Format

Send to:

Choose Destination

CHST2 carbohydrate sulfotransferase 2 [ Homo sapiens (human) ]

Gene ID: 9435, updated on 10-Dec-2019

Summary

Official Symbol
CHST2provided by HGNC
Official Full Name
carbohydrate sulfotransferase 2provided by HGNC
Primary source
HGNC:HGNC:1970
See related
Ensembl:ENSG00000175040 MIM:603798
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C6ST; GST2; GST-2; Gn6ST-1; HEL-S-75; glcNAc6ST-1
Summary
This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. [provided by RefSeq, Aug 2011]
Expression
Broad expression in spleen (RPKM 8.2), placenta (RPKM 6.8) and 22 other tissues See more
Orthologs

Genomic context

See CHST2 in Genome Data Viewer
Location:
3q24
Exon count:
2
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (143119771..143124014)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (142838618..142842856)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene U2 snRNP associated SURP domain containing Neighboring gene uncharacterized LOC105374138 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4297 Neighboring gene uncharacterized LOC105374137 Neighboring gene PBX homeobox 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Sulfate is linked to the carbohydrate chains of HIV-1 glycoproteins gp160, gp120, and gp41 during the endoplasmic reticulum to Golgi transport of the glycoproteins PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Glycosaminoglycan biosynthesis - keratan sulfate, organism-specific biosystem (from KEGG)
    Glycosaminoglycan biosynthesis - keratan sulfate, organism-specific biosystemKeratan sulfate (KS) is a glycosaminoglycan with the basic disaccharide unit of N-acetyllactosamine, Gal(b1-4)GlcNAc(b1-3), with sulfate esters at C-6 of GlcNAc and Gal residues. There are two types ...
  • Glycosaminoglycan biosynthesis - keratan sulfate, conserved biosystem (from KEGG)
    Glycosaminoglycan biosynthesis - keratan sulfate, conserved biosystemKeratan sulfate (KS) is a glycosaminoglycan with the basic disaccharide unit of N-acetyllactosamine, Gal(b1-4)GlcNAc(b1-3), with sulfate esters at C-6 of GlcNAc and Gal residues. There are two types ...
  • Glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
    Glycosaminoglycan metabolism, organism-specific biosystemGlycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)...
  • Keratan sulfate biosynthesis, organism-specific biosystem (from REACTOME)
    Keratan sulfate biosynthesis, organism-specific biosystemKeratan sulfate (KSI) is the best characterised keratan sulfate. It is 10 times more abundant in cornea than cartilage. KSI is attached to an asparagine (Asn) residue on the core protein via an N-lin...
  • Keratan sulfate/keratin metabolism, organism-specific biosystem (from REACTOME)
    Keratan sulfate/keratin metabolism, organism-specific biosystemKeratan sulfate (KS) (a glycosaminoglycan, GAG) is a linear polysaccharide that consists of the repeating disaccharide unit GlcNAc-Gal (N-acetylglucosamine-galactose). KS can perform a structural fun...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
  • Metapathway biotransformation, organism-specific biosystem (from WikiPathways)
    Metapathway biotransformation, organism-specific biosystem
    Metapathway biotransformation
  • chondroitin sulfate biosynthesis, organism-specific biosystem (from BIOCYC)
    chondroitin sulfate biosynthesis, organism-specific biosystem
    chondroitin sulfate biosynthesis
  • chondroitin sulfate biosynthesis (late stages), organism-specific biosystem (from BIOCYC)
    chondroitin sulfate biosynthesis (late stages), organism-specific biosystemGeneral Background : Chondroitin-sulfates "Chondroitin sulfate" is a sulfated : Glycosaminoglycans glycosaminoglycan" composed of alternating units of sulfated :CPD-12557 N-acetyl-beta-D-galactosami...

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetylglucosamine 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-acetylglucosamine 6-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
sulfotransferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
N-acetylglucosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-acetylglucosamine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
keratan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
sulfur compound metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfur compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intrinsic component of Golgi membrane NAS
Non-traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
carbohydrate sulfotransferase 2
Names
N-acetylglucosamine 6-O-sulfotransferase 1
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
carbohydrate (chondroitin 6/keratan) sulfotransferase 2
epididymis secretory protein Li 75
galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2
NP_004258.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029828.1 RefSeqGene

    Range
    4996..9239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004267.5NP_004258.2  carbohydrate sulfotransferase 2

    See identical proteins and their annotated locations for NP_004258.2

    Status: REVIEWED

    Source sequence(s)
    AC018450, BC042160, BX387933, CA431595
    Consensus CDS
    CCDS3129.1
    UniProtKB/Swiss-Prot
    Q9Y4C5
    UniProtKB/TrEMBL
    V9HVX9
    Related
    ENSP00000307911.3, ENST00000309575.5
    Conserved Domains (1) summary
    cl21551
    Location:311507
    Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    143119771..143124014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center