CD86 CD86 molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD86provided by HGNC
Official Full Name: CD86 moleculeprovided by HGNC
Primary source: HGNC:HGNC:1705
See related: Ensembl:ENSG00000114013 MIM:601020; AllianceGenome:HGNC:1705
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: B70; B7-2; B7.2; LAB72; CD28LG2
Summary: This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
Expression: Broad expression in appendix (RPKM 16.6), lymph node (RPKM 11.0) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q13.33

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (122055362..122121136)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (124775351..124841114)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (121774209..121839983)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

B cell-mediated CD4 T-cell costimulation via CD86 exacerbates pro-inflammatory cytokine production during autoimmune intestinal inflammation.
Title: B cell-mediated CD4 T-cell costimulation via CD86 exacerbates pro-inflammatory cytokine production during autoimmune intestinal inflammation.
Clinicopathologic Evaluation of CD80, CD86, and PD-L1 Expressions with Immunohistochemical Methods in Malignant Melanoma Patients.
Title: Clinicopathologic Evaluation of CD80, CD86, and PD-L1 Expressions with Immunohistochemical Methods in Malignant Melanoma Patients.
The levels of serum soluble CD86 are correlated with the expression of CD86 variant 3 gene and are prognostic indicators in patients with myeloma.
Title: The levels of serum soluble CD86 are correlated with the expression of CD86 variant 3 gene and are prognostic indicators in patients with myeloma.
Expression and Prognostic Value of CD80 and CD86 in the Tumor Microenvironment of Newly Diagnosed Glioblastoma.
Title: Expression and Prognostic Value of CD80 and CD86 in the Tumor Microenvironment of Newly Diagnosed Glioblastoma.
The Role of CD40, CD86, and Glutathione S-Transferase Omega 1 in the Pathogenesis of Chronic Obstructive Pulmonary Disease.
Title: The Role of CD40, CD86, and Glutathione S-Transferase Omega 1 in the Pathogenesis of Chronic Obstructive Pulmonary Disease.
PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface CD86 Expression, Growth, and Survival.
Title: PDZ Proteins SCRIB and DLG1 Regulate Myeloma Cell Surface CD86 Expression, Growth, and Survival.
Gene-environment interactions increase the risk of pediatric-onset multiple sclerosis associated with ozone pollution.
Title: Gene-environment interactions increase the risk of pediatric-onset multiple sclerosis associated with ozone pollution.
Cryptic association of B7-2 molecules and its implication for clustering.
Title: Cryptic association of B7-2 molecules and its implication for clustering.
Clinicopathological significance of CD28 overexpression in adult T-cell leukemia/lymphoma.
Title: Clinicopathological significance of CD28 overexpression in adult T-cell leukemia/lymphoma.
Multilocus evaluation of genetic predictors of multiple sclerosis.
Title: Multilocus evaluation of genetic predictors of multiple sclerosis.

Submit: New GeneRIF Correction See all GeneRIFs (166)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	The low mannose-level gp120 induces higher activation of plasmacytoid dendritic cells by upregulation of IFN-alpha, PD-L1, CD40, CCR7, CD80, and CD86 than the high mannose-level gp120 does	PubMed
	env	HIV-1 gp120 downregulates the expression of CD86 in human B cells	PubMed
	env	The presence of HIV-1 gp120 inhibits the oral mucosal pathogen Porphyromonas gingivalis-induced CD80, CD83, and CD86 upregulation	PubMed
Nef	nef	HIV-1 Nef downregulates CD86 from the cell surface in the human monocytic U937 cell line as well as in mouse macrophages and dendritic cells	PubMed
	nef	HIV-1 Nef co-localizes with MHC class I (MHCI), CD80, and CD86 in intracellular compartments by staining assays, and binds to both human CD80 and CD86 using yeast two-hybrid assays	PubMed
	nef	HIV-1 Nef binds to the cytosolic tails of CD80 and CD86 to mediate their internalization	PubMed
	nef	Activation and translocation of Src kinase is critical for Nef-mediated CD80 and CD86 internalization	PubMed
	nef	HIV-1 Nef relocates cell-surface MHC-I, CD80, and CD86 to intracellular compartments and the Nef-mediated internalization is dependent on mediators of actin polymerization	PubMed
Pr55(Gag)	gag	Expression of CD80, CD83, CD86, and HLA-DR molecules are significantly downregulated in mature dendritic cells after transduction with ubiquitinated Gag compared to unubiquitinated Gag constructs	PubMed
	gag	HIV-1 Gag virus-like particles efficiently activate human monocyte-derived dendritic cells (MDDC) and induce MDDC maturation with an associated increase in the surface expression of CD80, CD86 and MHC classes I and II	PubMed
	gag	HIV-1 Gag virus-like particle-induced monocyte activation is shown by upregulation of molecules involved in antigen presentation (MHC II, CD80, CD86) and cell adhesion (CD54)	PubMed
Tat	tat	HIV-1 Tat upregulates the expression of MHC and co-stimulatory molecules CD40, CD80, CD83 and CD86 in monocyte-derived dendritic cells, thereby driving T cell-mediated immune responses	PubMed
Vpr	vpr	HIV-1 Vpr inhibits the expression of co-stimulatory molecules including CD80, CD83, and CD86 at the transcriptional level without altering normal cellular transcription during dendritic cell maturation	PubMed
	vpr	HIV-1 Vpr downregulates the expression of several immunologically important molecules including CD40, CD80, CD83, and CD86 co-stimulatory molecules on monocyte-derived macrophage (MDM) and monocyte-derived dendritic cells (MDDC)	PubMed
capsid	gag	The immobilization of HIV-1 p24 antigen on the micelles upregulates the expression of cell surface markers CD80 and CD86 in human dendritic cells	PubMed
matrix	gag	Treatment of human PBMCs with HIV-1 MA upregulates the expression of MCP-1, ICAM-1, CD40, CD86 and CD36 and downregulates the expression of nuclear receptors FXR and PPARgamma	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH102182 (e-PCR)
- UniSTS:96516

RH11462 (e-PCR)
- UniSTS:78631

CD86_510 (e-PCR)
- UniSTS:277078

SHGC-147993 (e-PCR)
- UniSTS:172908

G31041 (e-PCR)
- UniSTS:3443

SGC35242 (e-PCR)
- UniSTS:5244

D3S2989 (e-PCR)
- UniSTS:32243

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables coreceptor activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor activity	TAS Traceable Author Statement more info	PubMed
enables virus receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in CD40 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell costimulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of phospholipase C activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in activation of protein kinase C activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T-helper 2 cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of immunoglobulin production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-2 production	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of interleukin-4 production	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of lymphotoxin A production	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	HDA more info	PubMed
located_in centriolar satellite	IDA Inferred from Direct Assay more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular exosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: T-lymphocyte activation antigen CD86

Names: B-lymphocyte activation antigen B7-2; BU63; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); CTLA-4 counter-receptor B7.2; FUN-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029928.2 RefSeqGene

Range

5002..70776

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001206924.2 → NP_001193853.2 T-lymphocyte activation antigen CD86 isoform 4 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC068630

Consensus CDS

CCDS56272.1

Related

ENSP00000420230.1, ENST00000493101.5

Conserved Domains (2) summary

cd00096
Location:27 → 33

Ig; Ig strand A [structural motif]

cl11960
Location:24 → 109

Ig; Immunoglobulin domain
NM_001206925.2 → NP_001193854.2 T-lymphocyte activation antigen CD86 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (5) is made from a downstream translation start site compared to isoform 1.

Source sequence(s)

AC068630

Consensus CDS

CCDS56273.1

Related

ENSP00000418988.1, ENST00000469710.5

Conserved Domains (2) summary

cd00096
Location:3 → 7

Ig; Ig strand D [structural motif]

cl11960
Location:1 → 51

Ig; Immunoglobulin domain
NM_006889.5 → NP_008820.4 T-lymphocyte activation antigen CD86 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) includes an alternate exon in the 5' UTR, resulting in the use of a downstream start codon compared to variant 1. Isoform 2 has a shorter N-terminus than isoform 1.

Source sequence(s)

AC068630

Consensus CDS

CCDS43138.1

UniProtKB/TrEMBL

A0A0X9R4E0

Related

ENSP00000377248.2, ENST00000393627.6

Conserved Domains (3) summary

cd00096
Location:133 → 139

Ig; Ig strand A [structural motif]

cd16087
Location:20 → 127

IgV_CD86; Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86

cl11960
Location:130 → 215

Ig; Immunoglobulin domain
NM_175862.5 → NP_787058.5 T-lymphocyte activation antigen CD86 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1) of this protein.

Source sequence(s)

AC068630

Consensus CDS

CCDS3009.1

UniProtKB/Swiss-Prot

A0N0P0, B7Z2F3, B7Z702, E7ETN5, E9PC27, P42081, Q13655, Q6FHB1, Q6GTS4, Q7M4L5

UniProtKB/TrEMBL

A8K632

Related

ENSP00000332049.2, ENST00000330540.7

Conserved Domains (2) summary

cd16087
Location:28 → 133

IgV_CD86; Immunoglobulin variable domain (IgV) in CD86

cl11960
Location:136 → 221

Ig; Immunoglobulin domain
NM_176892.2 → NP_795711.2 T-lymphocyte activation antigen CD86 isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) includes an alternate exon in the 5' UTR, resulting in the use of a downstream start codon compared to variant 1. It also lacks an in-frame exon compared to variant 1. The resulting isoform (3, also known as CD86deltaTM) has a shorter N-terminus and lacks an internal segment compared to isoform 1. This isoform is the soluble form of this protein.

Source sequence(s)

AC068630

Consensus CDS

CCDS74991.1

UniProtKB/TrEMBL

H7C4F8

Related

ENSP00000264468.6, ENST00000264468.9

Conserved Domains (3) summary

cd00096
Location:133 → 139

Ig; Ig strand A [structural motif]

cd16087
Location:20 → 127

IgV_CD86; Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86

cl11960
Location:130 → 215

Ig; Immunoglobulin domain