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KCNK6 potassium two pore domain channel subfamily K member 6 [ Homo sapiens (human) ]

Gene ID: 9424, updated on 22-Sep-2022

Summary

Official Symbol
KCNK6provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 6provided by HGNC
Primary source
HGNC:HGNC:6281
See related
Ensembl:ENSG00000099337 MIM:603939; AllianceGenome:HGNC:6281
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TOSS; KCNK8; TWIK2; K2p6.1; TWIK-2
Summary
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 7.3), esophagus (RPKM 6.3) and 24 other tissues See more
Orthologs
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Genomic context

See KCNK6 in Genome Data Viewer
Location:
19q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (38319845..38332076)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (41122020..41134251)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38810485..38822716)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene serine peptidase inhibitor, Kunitz type 2 Neighboring gene chromosome 19 open reading frame 33 Neighboring gene Yip1 interacting factor homolog B, membrane trafficking protein Neighboring gene Sharpr-MPRA regulatory region 11361 Neighboring gene cation channel sperm associated auxiliary subunit gamma Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human potassium channel, subfamily K, member 6 (KCNK6) at amino acid residues 42-43 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

General gene information

Homology

Clone Names

  • FLJ12282

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables inward rectifier potassium channel activity TAS
Traceable Author Statement
more info
PubMed 
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of resting membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of voltage-gated potassium channel complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
potassium channel subfamily K member 6
Names
K2P6.1 potassium channel
TWIK-originated similarity sequence
TWIK-originated sodium similarity sequence
inward rectifying potassium channel protein TWIK-2
potassium channel, two pore domain subfamily K, member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004823.3NP_004814.1  potassium channel subfamily K member 6

    See identical proteins and their annotated locations for NP_004814.1

    Status: REVIEWED

    Source sequence(s)
    AC026806
    Consensus CDS
    CCDS12513.1
    UniProtKB/Swiss-Prot
    Q9HB47, Q9Y257
    UniProtKB/TrEMBL
    B2RDS2
    Related
    ENSP00000263372.2, ENST00000263372.5
    Conserved Domains (1) summary
    pfam07885
    Location:180256
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    38319845..38332076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439726.1XP_047295682.1  potassium channel subfamily K member 6 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    41122020..41134251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)