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FOXQ1 forkhead box Q1 [ Homo sapiens (human) ]

Gene ID: 94234, updated on 10-Jun-2018
Official Symbol
FOXQ1provided by HGNC
Official Full Name
forkhead box Q1provided by HGNC
Primary source
HGNC:HGNC:20951
See related
Ensembl:ENSG00000164379 MIM:612788; Vega:OTTHUMG00000016160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HFH1
Summary
FOXQ1 is a member of the FOX gene family, which is characterized by a conserved 110-amino acid DNA-binding motif called the forkhead or winged helix domain. FOX genes are involved in embryonic development, cell cycle regulation, tissue-specific gene expression, cell signaling, and tumorigenesis (Bieller et al., 2001 [PubMed 11747606]).[supplied by OMIM, May 2009]
Orthologs
See FOXQ1 in Genome Data Viewer
Location:
6p25.3
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (1312440..1314758)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (1312675..1314993)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1622 Neighboring gene uncharacterized LOC105374879 Neighboring gene uncharacterized LOC107986554 Neighboring gene uncharacterized LOC112267978 Neighboring gene long intergenic non-protein coding RNA 1394 Neighboring gene uncharacterized LOC105374880

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of pancreatic cancer in Japanese population.
NHGRI GWA Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
NHGRI GWA Catalog
Linkage and association of successful aging to the 6q25 region in large Amish kindreds.
NHGRI GWA Catalog
  • Preimplantation Embryo, organism-specific biosystem (from WikiPathways)
    Preimplantation Embryo, organism-specific biosystemThe source of this pathway is RNA-Seq data from single-cell pre-implantation embryos (Supplemental Table 1): http://www.nature.com/nsmb/journal/v20/n9/full/nsmb.2660.html Analysis options for runnin...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
forkhead box protein Q1
Names
HFH-1
HNF-3/forkhead-like protein 1
hepatocyte nuclear factor 3 forkhead homolog 1
winged helix/forkhead transcription factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033260.3NP_150285.3  forkhead box protein Q1

    See identical proteins and their annotated locations for NP_150285.3

    Status: VALIDATED

    Source sequence(s)
    AL499606, BC053850, BU566731
    Consensus CDS
    CCDS4471.1
    UniProtKB/Swiss-Prot
    Q9C009
    Related
    ENSP00000296839.2, OTTHUMP00000017774, ENST00000296839.4, OTTHUMT00000043410
    Conserved Domains (1) summary
    cd00059
    Location:119197
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    1312440..1314758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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