Format

Send to:

Choose Destination

OPN4 opsin 4 [ Homo sapiens (human) ]

Gene ID: 94233, updated on 21-Dec-2019

Summary

Official Symbol
OPN4provided by HGNC
Official Full Name
opsin 4provided by HGNC
Primary source
HGNC:HGNC:14449
See related
Ensembl:ENSG00000122375 MIM:606665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOP
Summary
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See OPN4 in Genome Data Viewer
Location:
10q23.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (86653495..86666460)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (88414314..88426217)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378406 Neighboring gene ribosomal protein L7a pseudogene 8 Neighboring gene uncharacterized LOC105378409 Neighboring gene VISTA enhancer hs2143 Neighboring gene LIM domain binding 3 Neighboring gene bone morphogenetic protein receptor type 1A Neighboring gene RNA polymerase II associated protein 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of opsin 4 (OPN4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142118

Gene Ontology Provided by GOA

Function Evidence Code Pubs
11-cis retinal binding IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled photoreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled photoreceptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cellular response to light stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
detection of visible light IEA
Inferred from Electronic Annotation
more info
 
phototransduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phototransduction IDA
Inferred from Direct Assay
more info
PubMed 
protein-chromophore linkage IEA
Inferred from Electronic Annotation
more info
 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
photoreceptor disc membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030015.2NP_001025186.1  melanopsin isoform 2

    See identical proteins and their annotated locations for NP_001025186.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a longer protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AC067750, BC113558, BM672338, CD634966, CD634974
    Consensus CDS
    CCDS31237.1
    UniProtKB/Swiss-Prot
    Q9UHM6
    Related
    ENSP00000361141.2, ENST00000372071.6
    Conserved Domains (2) summary
    pfam00001
    Location:87361
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:78256
    7tm_4; Olfactory receptor
  2. NM_033282.4NP_150598.1  melanopsin isoform 1

    See identical proteins and their annotated locations for NP_150598.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC067750, BC113558, BM672338, CD634966
    Consensus CDS
    CCDS7376.1
    UniProtKB/Swiss-Prot
    Q9UHM6
    Related
    ENSP00000241891.5, ENST00000241891.10
    Conserved Domains (2) summary
    pfam00001
    Location:87350
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:78245
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    86653495..86666460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016957.1XP_016872446.1  melanopsin isoform X3

  2. XM_017016955.1XP_016872444.1  melanopsin isoform X1

  3. XM_017016956.1XP_016872445.1  melanopsin isoform X2

Support Center