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NTN1 netrin 1 [ Homo sapiens (human) ]

Gene ID: 9423, updated on 14-Jun-2020

Summary

Official Symbol
NTN1provided by HGNC
Official Full Name
netrin 1provided by HGNC
Primary source
HGNC:HGNC:8029
See related
Ensembl:ENSG00000065320 MIM:601614
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRMV4; NTN1L
Summary
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]
Expression
Broad expression in heart (RPKM 20.8), esophagus (RPKM 16.8) and 17 other tissues See more
Orthologs

Genomic context

See NTN1 in Genome Data Viewer
Location:
17p13.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (9021510..9244000)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8924859..9147317)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985063 Neighboring gene phosphoinositide-3-kinase regulatory subunit 5 Neighboring gene uncharacterized CTB-41I6.1 Neighboring gene uncharacterized LOC101928266 Neighboring gene uncharacterized LOC105371532 Neighboring gene uncharacterized LOC105371531 Neighboring gene syntaxin 8 Neighboring gene ribosomal protein L19 pseudogene 18 Neighboring gene cilia and flagella associated protein 52

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
MIRROR MOVEMENTS 4
MedGen: C4748869 OMIM: 618264 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
NHGRI GWA Catalog
Identification of inherited genetic variations influencing prognosis in early-onset breast cancer.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of netrin 1 (NTN1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Cdc42 protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
Ras protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anterior/posterior axon guidance IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
chemorepulsion of axon ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inner ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
negative regulation of netrin-activated signaling pathway TAS
Traceable Author Statement
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
nuclear migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell motility ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
substrate-dependent cell migration, cell extension ISS
Inferred from Sequence or Structural Similarity
more info
 
tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
netrin-1
Names
epididymis tissue protein Li 131P
netrin 1, mouse, homolog of

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004822.3NP_004813.2  netrin-1 precursor

    See identical proteins and their annotated locations for NP_004813.2

    Status: REVIEWED

    Source sequence(s)
    AC005695, AC090610, U75586
    Consensus CDS
    CCDS11148.1
    UniProtKB/Swiss-Prot
    O95631
    Related
    ENSP00000173229.2, ENST00000173229.7
    Conserved Domains (4) summary
    smart00136
    Location:46283
    LamNT; Laminin N-terminal domain (domain VI)
    cd00055
    Location:284329
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03579
    Location:487601
    NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
    pfam00053
    Location:404441
    Laminin_EGF; Laminin EGF domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    9021510..9244000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721595.3XP_006721658.1  netrin-1 isoform X1

    See identical proteins and their annotated locations for XP_006721658.1

    UniProtKB/Swiss-Prot
    O95631
    Conserved Domains (4) summary
    smart00136
    Location:46283
    LamNT; Laminin N-terminal domain (domain VI)
    cd00055
    Location:284329
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03579
    Location:487601
    NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
    pfam00053
    Location:404441
    Laminin_EGF; Laminin EGF domain
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